Korean J Anesthesiol Search

CLOSE


Korean J Anesthesiol > Volume 37(5); 1999 > Article
Korean Journal of Anesthesiology 1999;37(5):885-892.
DOI: https://doi.org/10.4097/kjae.1999.37.5.885   
Effects of L-Arginine and N-Nitro-L-Arginine Metheylester Treatment on Vasodilation of Propofol in Rat Thoracic Aortic Rings.
Mi Hee Ha, Hyun Ho Son, Dong Gun Lim, Woon Yi Baek, Jung Gil Hong, Byung Kwon Kim, Jin Woong Park
Department of Anesthesiology, School of Medicine, Kyungpook National University, Taegu, Korea.
Abstract
BACKGROUND
Propofol decreases arterial blood pressure. This has been ascribed to vasodilation and decreased cardiac output occurring separately or in combination. This study investigated the relaxant effects of propofol and the effects of L-arginine and L-NAME on the vasodilation of propofol in rat thoracic aortic rings.
METHODS
Isolated aortic rings were precontracted with phenylephrine (0.01 micrometer -10 micrometer) cumulatively and 10 minutes before the precontracted phenylephrine treatment, propofol was added cumulatively (1 micrometer-10 micrometer). The effects of L-NAME and L-arginine were evaluated by applying L-NAME (10 micrometer) and L-arginine (10 micrometer) after added propofol and before precontracted phenylephrine.
RESULTS
A low concentration of propofol (1 micrometer) did not reduce phenylephrine-induced contraction but a high concentration of propofol (over 10 micrometer) reduced it significantly. Propofol also relaxed rat thoracic aortic rings in an endothelium independent manner. The L-NAME and L-arginine treatment did not affect the propofol-induced relaxation.
CONCLUSIONS
Propofol was shown to have a biphasic vasoactive effect on rat thoracic aorta rings. The vasodilation effect of propofol was not related to the production of nitric oxide.
Key Words: Anesthetics, intravenous, propofol; Pharmacology, L-arginine, L-NAME
TOOLS
Share :
Facebook Twitter Linked In Line it
METRICS Graph View
  • 1 Crossref
  •    
  • 860 View
  • 0 Download


ABOUT
ARTICLE CATEGORY

Browse all articles >

BROWSE ARTICLES
AUTHOR INFORMATION
Editorial Office
101-3503, Lotte Castle President, 109 Mapo-daero, Mapo-gu, Seoul 04146, Korea
Tel: +82-2-792-5128    Fax: +82-2-792-4089    E-mail: journal@anesthesia.or.kr                

Copyright © 2023 by Korean Society of Anesthesiologists.

Developed in M2PI

Close layer
prev next