| The Postoperative Antiemetic Effect of Midazolam in Patients Undergoing Appendectomy. |
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Sang Yoon Cho, Mi Kyung Oh, Jong Hoon Yeom, Woo Jong Shin, Yong Chul Kim, Dong Ho Lee |
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Department of Anesthesiology, Hanyang University College of Medicine, Suwon, Korea. |
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| Abstract |
BACKGROUND
Postoperative nausea and vomiting are common postoperative complaints. The purpose of this study was to assess the effect of preoperative midazolam on vomiting after appendectomy.
METHODS
Sixty patients, aged 10 64 yr, undergoing emergency appendectomy were randomly allocated to receive midazolam 30, 50, 75 microgram/kg or placebo after induction of anesthesia. Anesthesia consisted of 67% nitrous oxide, 33% oxygen and propofol infusion 6 10 mg/kg/h. Postoperative vomiting was checked by the recovery room nurse at 1 h after operation and we examined the incidence of postoperative vomiting at 24 h after operation.
RESULTS
Midazolam reduced the overall incidence of vomiting, especially in the midazolam 50 and 75 microgram/kg groups, completely abolishing vomiting (P< 0.05). However, in the midazolam 75 microgram/kg group, there was a delay in eye opening time (P< 0.05).
CONCLUSIONS
Preoperative injections of midazolam 30 or 50 microgram/kg were useful to prevent postoperative vomiting in patients undergoing appendectomy without delayed recovery. |
| Key Words:
Anesthetics, intravenous, propofol; Antiemetics, midazolam; Complication, vomiting; Surgery, appendectomy |
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