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Korean J Anesthesiol > Volume 40(3); 2001 > Article
Korean Journal of Anesthesiology 2001;40(3):282-292.
DOI: https://doi.org/10.4097/kjae.2001.40.3.282   
Evaluation of Marsh's Pharmacokinetic Parameter Set for Target Controlled Infusion of Propofol in Korean.
Soon Young Jeon, Ho Yeong Kil, Kwang Min Kim
Department of Anesthesiology, Hallym University College of Medicine, Seoul, Korea.
Marsh's pharmacokinetic parameter set is the most widely used parameter for target controlled infusion for propofol. However, Marsh's model was derived from a European population, and it is uncertain whether this model is accurate for Koreans.
Thirty ASA 1 or 2 adult patients undergoing orthopedic surgery participated in this study. Atropine 0.5 mg was injected for premedication. Anesthesia was induced by a TCI of propofol with a target concentration of 6 microgram/ml and maintained around 3 - 5 microgram/ml according to the bispectral index (35 - 45). In the middle of surgery, target concentrations were increased to 6 microgram/ml and maintained until effect site concentration was the same concentration. Three minutes after equilibration, 3 ml of blood was drawn from the radial artery and contralateral antecubital cephalic vein for measuring blood concentration using HPLC. Target concentrations were gradually decreased at the interval of 1 microgram/ml until the end of surgery and a blood sample was drawn as described in the method. A sample for every 1 microgram/ml was collected in the recovery room. Performance error of the predicted concentration of blood was calculated.
The performance error was -12.86 - 16.55% for 1 - 6 microgram/ml of predicted concentration. Measured concentrations were higher than predicted at higher concentrations, but lower at lower concentrations. Measured cardiac output and arteriovenous concentration differences at 1 - 6 microgram/ml showed no difference.
Marsh's pharmacokinetic model was accurate for propofol TCI in Koreans in terms of relatively low performance error (< 20%) in the concentration range of 1 - 6 microgram/ml.
Key Words: Anesthetics, intravenous: propofol; Pharmacokinetics: pharmacokinetic parameter; Statistics: performance error
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