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Korean J Anesthesiol > Volume 40(4); 2001 > Article
Korean Journal of Anesthesiology 2001;40(4):515-521.
DOI: https://doi.org/10.4097/kjae.2001.40.4.515   
Comparison of Poloxamer-407 to Soybean Oil as an Emulsifying Agent for Propofol: Histamine Release and Plasma Lipid Levels.
Hyun Hwa Lee, Ho Yeong Kil, Tae Hyun Han, Hoon Park, Sung Il Shin, Hyun Jung Yang, Min Ku Kim, Dae Woo Kim
1Department of Anesthesiology, College of Medicine, Hallym University.
2Department of Orthopaedic Surgery, College of Medicine, Hallym University.
3Department of Anesthesiology, College of Medicine, Pochun Choong-Moon University.
4The Catholic University of Korea, Seoul, Korea.
Abstract
BACKGROUND
To reduce side effects (hyperlipidemia, pain on injection, etc.) of the present formation of propofol, many attempts to change the emulsifying agent for propofol have been tried. This study was designed to examine the poloxamer-407 as an emulsifying agent for propofol compared to soybean oil regarding histamine release and plasma lipid levels.
METHODS
Twelve Beagle dogs weighing 12 - 16 kg were randomly assigned to one of two groups according to the formulation of propofol. Group 1 received Diprivan propofol 1% (AstraZeneca Co. UK), and group 2 received poloxamer-407 formulated propofol by a continuous intravenous infusion at 30 mg/kg/h for 3 hours. Three, 6, 9 and 12 hours after discontinuing the propofol infusion, venous blood samples from the cranial tibial vein were analysed by an ELISA kit for the histamine level. Also, blood lipid levels were checked 3 hours after the infusion and blood propofol concentration were checked every hour during the infusion.
RESULTS
Group 2 showed significantly less histamine release than group 1 at 3, 6 and 9 hours after the infusion (P < 0.05). In the plasma lipid study, there was no difference in high-density lipoprotein (HDL) between the two groups, but triglyceride and cholesterol were significantly higher in group 2 (P < 0.05). There was no difference in propofol concentrations between the two groups.
CONCLUSIONS
Poloxamer-407 as an emulsifying agent for propofol showed no advantage compared to a present formulation regarding hyperlipidemia, and even decreased the histamine level.
Key Words: Allergy: anaphylaxis; histamine; Anesthetics, intravenous: propofol; Complications: hematology; hyperlipidemia; Research: poloxamer-407
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