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Korean J Anesthesiol > Volume 35(1); 1998 > Article
Korean Journal of Anesthesiology 1998;35(1):120-124.
DOI: https://doi.org/10.4097/kjae.1998.35.1.120   
Intra-articular Morphine for Pain Relief after Arthroscopic Knee Surgery.
Sun Joon Bai, Bum Joon Cho, Soon Ho Nam, Haeng Chul Lee, Eun Kyoung Ahn
Department of Anesthesiology, Yonsei University, College of Medicine, Seoul, Korea.
Abstract
BACKGROUND
Opioids can produce potent antinociceptive effects by interacting with local opioid receptors in inflamed peripheral tissue. However, reports on pain relief with intra-articular morphine after arthroscopic knee operations are conflicting. In this study we examined the analgesic effects of the intraarticular administration of morphine after knee surgery.
METHODS
In a double-blind, randomized trial, we studied 26 patients who had received one of two injections at the end of surgery. The patients in group M(n=11) received 3 mg of morphine intraarticularly; those in group P(n=15), saline 20 ml intraarticularly as a placebo.
RESULTS
Patients in the morphine group had significantly lower pain scores throughout the 24-h postoperative period compared with those in the placebo group(P<0.05). There was less requirement for supplementary analgesics in the morphine group.
CONCLUSIONS
Low doses of intraarticular morphine can significantly reduce pain after knee surgery without any systemic side effect.
Key Words: Analgesia: postoperative; Analgesic technique: intraarticular; Analgesics: morphine; Surgery: arthroscopy; knee


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