| The Effect of Propofol on Pruritus induced by Epidural Morphine. |
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Mi Kyeong Lee, Sang Ho Lim, In Ho Lee, Seok Min Yoon, Young Seok Choi |
1Department of Anesthesiology, College of Medicine Korea University, Seoul, Korea.
2Department of Anesthesiology, Seoul National University College of Medicine, Seoul, Korea. |
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| Abstract |
BACKGROUND
Epidural morphine is used commonly for postoperative pain control. But, pruritus, although trivial, is a common side effect. It is reported that subhypnotic doses of propofol are effective against pruritus induced by epidural or subarachnoid morphine.
METHODS
Sixty five patients received epidural morphine 4 mg bolus and 4 mg/day with continuous infusion for 2 days via Baxter infusor. The patients who have pruritus with scratching were allocated randomly to receive either 1 ml propofol(10 mg) or 1 ml placebo(Intralipos ) intravenously.
Pruritus was assessed 5 min later using a pruritus rating scale with double-blind, placebo-controlled study.
RESULTS
Forty patients showed pruritus with scratching. The overall success rate in treating pruritus was 75% in propofol group and 25% in placebo group. Compared with placebo, propofol was effective significantly(P<.05).
CONCLUSIONS
These results suggest that propofol in a subhypnotic dose is an efficient drug treatment for epidural morphine induced pruritus. |
| Key Words:
Analgesics; morphine; Anesthetic techniques; epidural; Anesthetics; intravenous; propofol; Complications; pruritus |
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