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Korean Journal of Anesthesiology 1997;32(3):423-426.
DOI: https://doi.org/10.4097/kjae.1997.32.3.423   
The Effect of Propofol on Pruritus induced by Epidural Morphine.
Mi Kyeong Lee, Sang Ho Lim, In Ho Lee, Seok Min Yoon, Young Seok Choi
1Department of Anesthesiology, College of Medicine Korea University, Seoul, Korea.
2Department of Anesthesiology, Seoul National University College of Medicine, Seoul, Korea.
Abstract
BACKGROUND
Epidural morphine is used commonly for postoperative pain control. But, pruritus, although trivial, is a common side effect. It is reported that subhypnotic doses of propofol are effective against pruritus induced by epidural or subarachnoid morphine.
METHODS
Sixty five patients received epidural morphine 4 mg bolus and 4 mg/day with continuous infusion for 2 days via Baxter infusor. The patients who have pruritus with scratching were allocated randomly to receive either 1 ml propofol(10 mg) or 1 ml placebo(Intralipos ) intravenously. Pruritus was assessed 5 min later using a pruritus rating scale with double-blind, placebo-controlled study.
RESULTS
Forty patients showed pruritus with scratching. The overall success rate in treating pruritus was 75% in propofol group and 25% in placebo group. Compared with placebo, propofol was effective significantly(P<.05).
CONCLUSIONS
These results suggest that propofol in a subhypnotic dose is an efficient drug treatment for epidural morphine induced pruritus.
Key Words: Analgesics; morphine; Anesthetic techniques; epidural; Anesthetics; intravenous; propofol; Complications; pruritus


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