| Interaction of Magnesium Sulfate with Mivacurium-induced Neuromuscular Block in Rabbits. |
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Kyo Sang Kim, Seog Kyu Won, Jae Ki Lee |
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Department of Anesthesiology, Hanyang University, College of Medicine, Seoul, Korea. |
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| Abstract |
BACKGROUND
Magnesium sulfate(MgSO4) has long been used in the treatment of pre-eclampsia and hypertension. Mivacurium was found to undergo hydrolysis by plasma cholinesterase at 70-88% of the rate of succinylcholine. This study has been conducted to evaluate the time course of mivacurium-induced neuromuscular block according to the pretreatment doses of MgSO4 in rabbits.
METHODS
This study was done using a common peroneal nerve-anterior tibialis muscle preparation in sixty adult rabbits. The onset and recovery times of mivacurium(0.16 mg/kg) were evaluated after the infusion of a placebo in group 1, MgSO4 30 mg/kg in group 2, MgSO4 50 mg/kg in group 3 and MgSO4 70 mg/kg in group 4, respectively(n=15 each).
RESULTS
The mean serum concentration of magnesium was 2.4 mEq/L in group 1, 3.3 mEq/L in group 2, 4.3 mEq/L in group 3 and 5.5 mEq/L in group 4, respectively. The mean time from injection of mivacurium to 95% recovery of twitch amplitude was 32.7 min. in group 1, 32.9 min. in group 2, 30.4 min. in group 3 and 33.0 min. in group 4, respectively.
CONCLUSIONS
The results of the present study suggested that the neuromuscular blocking actions of mivacurium are not affected according to the pretreatment doses of MgSO4. |
| Key Words:
Neuromuscular relaxants; Mivacurium; Ions; Magnesium |
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