An Experimental Study on the Vasopressor Effects of Various Sympathomimetic Amines in Reserpinized Dogs during N₂O-O₂-Halothane Anesthesia.

Kim,  Kwang Woo; Shin,  Kwang II; Choi,  Soo Hong; Kim,  Yong Lack; Kwak,  II Young

doi:1972.5.2.113

Korean Journal of Anesthesiology 1972;5(2):113-120.
DOI: https://doi.org/10.4097/kjae.1972.5.2.113

Kwang Woo Kim, Kwang II Shin, Soo Hong Choi, Yong Lack Kim, II Young Kwak

Department of Anesthesiology, Seoul National University, College of Medicine, Seoul, Korea.

Abstract

Vasopressor effects of epinephrine, norepinephrine, ephedrine, phenylephrine, methoxamine and of mephentermine were compared in resrpinized dogs with or without nitrous oxide-oxygen-halothane anesthesia. The results are as follows: (1) Epinephrine and norepinephrine were shown to have the most potent pressor effect in reserpinized and nitrous oxide-oxygen-halothane-anesthetized dogs. Phenylephrine, methoxamine, mephen-termine and ephedrine were less potent in decreasing order. (2) Decrease in mean arterial pressure was less marked in dogs reserpinized and anesthetized with nitrous oxide-oxygen-halothane than in reserpinized but unanesthetized dogs. (3) It revealed that nitrous oxide-oxygen-halothane anesthesia potentiated the vasopressor effects of the sympathomimetic amines studied. Nitrous oxide-oxygen-halothane anesthesia is implicated to exert an sympathomimetic effect.