| Salmon-Calcitonin; Analgesic Effect and Influence on the Morphine Induced Analgesia. |
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Jeong Gill Leem |
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Department of Anesthesiology, College of Medicine, University of Ulsan, Korea. |
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| Abstract |
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Calcitonin is a peptide hormone involved primarily in the regulation of calcium homeostasis. However,clinical observations have shown that calcitonin does in fact possess an analgesic effect in a variety of painful disorders. So I studied the analgesic effect of intracerebroventricularly(i.c.v.) administered salmon calcitonin(s-CT) using the hot plate test and writhing test.
The influence on the analgesia induced by morphine and naloxone reversibility was also studied. When s-CT was administered i.c.v., analgesia was observed in both tests,although it was greater in the writhing test than in the hot plate test. The analgesic effect of s-CT was partially but significantly reversed by naloxone. Thus, these results provide information about the antinociceptive effect of s-CT via interaction with both opiate and non-opiate mechanisms. |
| Key Words:
salmon-Calcitonin; Morphine; Analgesia |
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