Continuous Intravenous Infusion of Propofol and Succinylcholine Supplemented with Nitrous Oxide in Short Duration of Microlaryngeal Surgery Comparison with Thiopental/Enflurane-N2O and Succinylcholine Infusion.

Lee,  Hye Won; Chae,  Byung Kook; Choi,  Jong Ouck; Chang,  Seong Ho

doi:1996.31.5.624

Korean Journal of Anesthesiology 1996;31(5):624-628.
DOI: https://doi.org/10.4097/kjae.1996.31.5.624

Hye Won Lee, Byung Kook Chae, Jong Ouck Choi, Seong Ho Chang

¹Department of Anesthesiology, School of Medicine, Korea University, Seoul, Korea.
²Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Korea University, Seoul, Korea.

Abstract

BACKGROUND
Anesthetic technique for laryngeal microscopic surgery should be focused on rapid recovery of deep anesthesia and full muscle relaxation. This study was taken to evaluate the effect of continuous infusion of propofol and succinylcholine for this kind of anesthetic goal.
METHODS
Forty patients scheduled for laryngeal microscopic surgery of short duration(15 min) were randomly allocated into two groups. Anesthesia was induced and maintained with either propofol(2.5 mg/kg followed by a continuous infusion of 0.1 mg/kg/min) in group P or with thiopental (5.0 mg/kg) and inhalation of 1~2 vol % enflurane for maintenance of anesthesia in group T/E. Succinylcholine(1 mg/kg followed by continuous infusion of 0.1 mg/kg/min) was administered to facilitate tracheal intubation and maintain neuromuscular blockade.
RESULTS
No significant difference of duration of anesthesia appeared between two groups. Additional doses of succinylcholine were needed in 10% of group P and 30% of group T/E (p<0.05). In group P, time to response to suction catheter(136+/-54 vs 232+/-116 sec), time to eye open spontaneously or to verbal commands (368+/-142 vs 549+/-165 sec) and time to extubation (454+/-117 vs 647+/-181 sec) were significantly shorter comparing to group T/E. The quality of awakening was more favorable in group P(p<0.05). Laryngeal suspension induced bradycardia in 15% of group P and in 5% of group T/E. Both group P and group T/E (10% vs 30%) needed esmolol infusion to control the blood pressure during surgical procedure.
CONCLUSIONS
Rapid recovery of anesthesia and muscle relaxation can be expected after continuous infusion of propofol(2.5 mg/kg followed by 0.1mg/kg/min) and succinylcholine(1 mg/kg followed by 0.1 mg/kg/min) supplemented with 50% N2O in 50% O2 for short duration of laryngeal microscopic surgery.

Key Words: Anesthetics,intravenous propofol; Anesthetics; volatile enflurane; Neuromuscular relaxant succinylcholine; Anesthetic Technique intravenous