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Korean J Anesthesiol > Volume 26(5); 1993 > Article
Korean Journal of Anesthesiology 1993;26(5):975-981.
DOI: https://doi.org/10.4097/kjae.1993.26.5.975   
Dose - response for Atropine and Heart Rate in Children during Inhalation Anesthesia.
Jae Hyon Bahk, Mi Kyung Yang, Seung Woon Lim, Seong Deok Kim
1Department of Anesthesiology, College of Medicine, Seoul National University, Seoul, Korea.
2Department of Anesthesiology, College of Medicine, Chungbuk National University, Chungbuk, Korea.
Abstract
We determined the dose-response for atropine and heart rate in 114 healthy children anesthetized with N2O-O2-1 MAC halothane, enflurane or isoflurane. After induction of anesthesia, atmpine in does of 5, 10, 20 and 30 ug/kg was administered successively by rapid intravascular infusion with a time interval to each subject. The effects of atropine on heart rate and systolic blood pressure were compared among anesthetic groups and dosage groups, and a dose-response curve for peak heart rate was constructed in each anesthetic group. The heart rate increased in all cases following atropine medication. Among the dosage group of 5 ug/kg, the heart rate was significantly highest in children receiving isoflurane anesthesia (p<0.05). Among 10 and 20 ug/kg, the heart rate was significantly lowest in enflurane group. In 30 ug/kg, the heart rate was not different in eaeh anesthetic group. In each dosage group, the systolic blood pressure was significantly lowest in isoflurane gorup (p<0.05). In children anesthetized with halothane. 50% maximal response corresponded to 7.8 ug/kg, and 90% maximal response corresponded to 16.5 ug/kg. In enflurane group, 50% maximal response corresponded to 9.5 ug/kg, and 90% maximal response corresponded to 23.0 ug/kg. In isoflurane group, 50% maximal response corresponded to 7.5 ug/kg, and 90% maximal response corresponded to 18.3 ug/kg. Based on these data we conclude that 10 ug/kg of atopine is minimally required to increase heart rate by 50% of peak heart rate in children anesthetized with N2O-O2-1 MAC halothane, enflurane or isoflurane and that this also increases systolic blood pressure.
Key Words: anesthesia; Children; atropine; dose-response; halothane; enflurane; isoflurane


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