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Korean Journal of Anesthesiology 1993;26(6):1284-1288.
DOI: https://doi.org/10.4097/kjae.1993.26.6.1284   
A Case of Withdrawal Symptom after Injection of Nalbuphine in a Chronically Morphine-Dependent Patient.
Kwang Tae Cho, Sang Chul Lee, Kwang Won Yum, Seok Kon Kim, Dong Hee Kim
1Department of Anesthesiology, Seoul National University Medical College, Seoul, Korea.
2Department of Anesthesiology, Seoul National University Dental College, Seoul, Korea.
Nalbuphine, a mixed agonist-antagonist type opioid, can precipitate abstinence syndrome in opioid-dependent patients especially in large doses. We can prevent this syndrome by avoiding the injection of agonist-antagonist type opioid to the patient who already has used opioid for a long time, and the method of relatively small dose increments in its use. We experienced a case of opioid withdrawal symptom in chronically morphine-administered patient via epidural catheter after using intramuscular nalbuphine for analgesia. The symptom was promptly relieved by intravascular morphine injection without any problems.
Key Words: Withdrawal Symptom; Nalbuphine; Morphine


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