Korean J Anesthesiol Search


Korean Journal of Anesthesiology 1990;23(4):577-580.
DOI: https://doi.org/10.4097/kjae.1990.23.4.577   
Plasma Cholinesterase Activity and Reaction of Succinylcholine in Late Pregnancy.
Sang Chul Bae, Chan Soo Han, Soon Im Kim, Sun Chong Kim, Sung Yell Kim
Department of Anesthesiology, College of Medicine, Soon Chun Hyang University, Seoul, Korea.
Plasma cholinesterase (ChE), an enzyme produced by the liver, rapidly hydrolizes succinylcholine. In the presence of low enzymatic activity, the rate of destruction of succinylcholine is diminished and it may result in an undesirably long duration of paralysis following succinylcholine administration. There are many reports that a significant fall in plasma ChE activity was shown to occur during pregnancy and in the immediate postpartum period. The present study was designed to compare the plasma ChE activity and the reaction of succinylcholine in 27 healthy nonpregnant women with that in 30 pregnant women undergoing elective caesarean section. Before induction of anesthesia, venous blood was taken for the measurement of plasma ChE activity, which was assayed by a colorimetric method, and the duration of action, recovery index and TOF ratio of succinylcholine were measured using ABM (Anesthesia and Brain activity Monitor, Datex Co.). The results were as follows: 1. Plasma ChE aetivity in pregnant women was lower than in nonpregnant women but was not statistically significant. 2. With respect to the duration of action, recovery index and TOF ratio on the 25 and 75% recovery of first twitch height, there were no significant differences between pregnant and nonpregant women.
Key Words: Plasma eholinesterase; Succinylcholine; Pregnancy


Browse all articles >

Editorial Office
101-3503, Lotte Castle President, 109 Mapo-daero, Mapo-gu, Seoul 04146, Korea
Tel: +82-2-792-5128    Fax: +82-2-792-4089    E-mail: journal@anesthesia.or.kr                

Copyright © 2024 by Korean Society of Anesthesiologists.

Developed in M2PI

Close layer
prev next