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Korean Journal of Anesthesiology 1991;24(5):979-985.
DOI: https://doi.org/10.4097/kjae.1991.24.5.979   
The Effect of Neostigmine Pretreatment on Vecuronium Induced Neuromuscular Blockade.
Bong Ho Shin, Sang Ho Lim, Young Seok Choi, Seok Min Yoon, Il Ok Lee, Nan Suk Kim, Byung Gee Kim
Department of Anesthesiology, College of Medicine, Korea University, Seoul, Korea.
Abstract
Prolonged neuromuscular blockade following succinylcholine may be seen when anticho- linesterase had been administered prior to reverse nondepolarizing muscle relaxant-induced paralysis, possibly anticholinesterase has been reported to inhibit serum cholinesterase activity. Our study was undertaken in order to understand the effect of a nondepolarizing muscle relaxant (vecuronium) following neostigmine pretreatment. In this study, we assessed the effect of vecuronium induced neuromuscular blockade using a train of four, 2 Hz stimulations on ulnar nerve. Patients admitted to our hospital for elective operations were divided into two groups, each group consisting of 16 patients. In group I, vecuronium 0.1 mg/kg was .administered according to the priming principle following normal saline, in group II, vecuronium 1.0mg/kg was administered according to the priming principle following neostigmine 0.05 mg/kg and glycopyrrolate 0.003 mg/kg pretreatment. Then the time for Tl to reach 5% or less(second), and the time for Tl to reach from 25% to 75%(recovery index) were measured in both groups. The time for Tl to reach 5% or less in group I(92.8+/-14.72 second) and group II(97.5+/-16.43 seconds) were not siginificant. However the recovery indexof group I(10.2 5+/-1.93 minute) and group II(8.5+/-1.80 minute) showed significant shortening in group II(p<0. 05)
Key Words: Anticholinesterase-neostigmine; Nondepolarizing muscle relaxant-vecuronium; Serum cholinesterase; Priming principle; Glycopyrrolate; TOF- T1; Recovery index


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