| The Effect of Verapamil on Cardiovascular Response to Tracheal Intubation. |
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Young Chul Park, Hong Hyeun Ryu, Seong Wan Baik, Kyoo Sub Chung, In Chan Choi |
1Department of Anesthesiology, College of Medicine, Pusan National University, Pusan, Korea.
2Department of Anesthesiology, St. Benedict Hospital, Pusan, Korea. |
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| Abstract |
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To evaluate the efficacy of verapamil to prevent sympathetic stimulation during endotracheal intubation. Author studied the cardiovascular responses to laryngoscopy and endoracheal intubation in 60 patients who received verapamil 0.075 mg/kg, 0.15 mg/kg or no verapamil medication before the larngoscopy. The index of'cardiovascular response during laryngoscopy and tracheal intubation were mean arterial pressure(MAP), heart rate(HR), and rate pressure product(RPP). And author concluded as follows. l) The changes of MAP were more stable in verapamil groups than no verapamil group(P 0.05). But there were no difference between verapamil 0.075 mg/kg and 0.15 mg/kg groups. 2) The changes of HR were more stable in verapamil group until 5 minutes after tracheal intubation. In difference between verapamil 0.015 mg/kg and 0.15 mg/kg, verapamil 0.15 mg/kg(P 0.01) were more stable than 0.075 mg/kg group(P 0.005). 3) The canges of RPP were more stable in verapamil group until 10 min. after tracheal intubation. But there were no difference in verapamil 0.075 mg/kg and 0.15 mg/kg group. |
| Key Words:
Intubation; verapamil; RPP; Blood pressure; Heart rate |
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