The Effect of Venovenous Extracorporeal Lung Assist on the Arterial Oxygen Tension in Hypoxic Dogs.

Lee,  Kook Hyun; Ham,  Byung Moon; Jung,  Sung Eun

doi:1992.25.1.72

Clinical Research Article

Korean Journal of Anesthesiology 1992;25(1):72-77.
DOI: https://doi.org/10.4097/kjae.1992.25.1.72

The Effect of Venovenous Extracorporeal Lung Assist on the Arterial Oxygen Tension in Hypoxic Dogs.

Kook Hyun Lee, Byung Moon Ham, Sung Eun Jung

¹Department of Anesthesiology, Seoul National University College of Medicine, Seoul, Korea.
²Department of Surgery, Seoul National University College of Medicine, Seoul, Korea.

Abstract

Neonatal venoarterial(VA) extracorporeal lung assist(ECLA) drains venous blood from the right atrium via the right internal jugular vein and perfuses oxygenated blood to the aortic arch via the right common carotid artery. Though VA ECLA supports cardiac function, it is not free from neurologic complications due to ligation of the carotid artery. Venovenous(VV) bypass is used early for acute respiratory failure. To reduce the number of veins ligated, a double lumen tube was developed. VV ECLA using the double lumen tube was tried on eight hypoxic dogs at F1O2 0.15. Control values of hemodynamics and blood gases were obtained while the 0.8 m kolobow lung ventilated with nitrogen gas. We measured the same parameters while ventilating the oxygenator with oxygen(ECLA on). Mean arterial pressure and mean pulmonary arterial pressure were decreased significantly during ECLA on. Bypass flow rate was 1042+/-72ml/min and bypass ratio(bypass flow rate cardiac output X100) was 40+/-15%. Arterial oxygen tension was increased from 52+/-14mmHg to 79+/-23mmHg during ECLA on, whose saturation was 94+/-2%. Venous drainage was limited with a double lumen tube, but it can be used clinically for moderate hypoxemia with ease.

Key Words: Venoarterial(VA); Extracorporeal lung assist(ECLA); Venovenous(VV); Double Lumen tube; Bypass flow rate; Bypass ratio; Hypoxemia