Korean J Anesthesiol Search


Korean J Anesthesiol > Volume 25(1); 1992 > Article
Korean Journal of Anesthesiology 1992;25(1):114-120.
DOI: https://doi.org/10.4097/kjae.1992.25.1.114   
Effects of Fentanyl - Oxygen Anesthesia on Serum Catecholamine during Open Heart Surgery.
Chong Sung Kim, Jae Hyon Bahk, Sang Tae Kim, Yong Chul Kim, Kwang Woo Kim
1Department of Anesthesiology, College of Medicine, Seoul National University, Seoul, Korea.
2Department of Anesthesiology, Central Army Force Hospital, Seoul, Korea.
Serum epinephrine and norepinephrine concentrations were measured in 7 patients during fentanyl-oxygen anesthesia, who were undergoing elective open heart surgery(single valvular replacement operations) in Seoul National University Hospital. Sampling times and corresponding total fentanyl doses were as follows; 1) after arterial cannulation 2) 5 minutes after intubation(50 ug/kg of B. Wt) 3) 5 minutes after sternotomy(65 ug/ka) 4) after aortic dissection(75 ug/kg) 5) 15 minutes after initiating bypass 6) 60 minutes after initiating bypass [20 ug/kg of fentanyl was added to the priming solution before initiation of Cardio-pulmonary bypass(CP bypass)]. High Performance Liquid Chromatography(HPLC) was used to analyze hormones. Epinephrine concentrations(pg/ml) corresponding to the sampling times were as follows (mean+/-SE); 1) 213+/-59 2) 199+/-62 3) 246+/-83 4) 173+/-35 5) 270+/-70 6) 269+/-70 Norepinephrine concentrations(pg/ml) were as follows(mean+/-SE); 1) 609+/-107 2) 500+/-73 3) 645+/-152 4) 470+/-82 5) 494+/-65 6) 955+/-311 There were no significant hormonal changes except the 6th norepinephrine value. There were no significant hemodynamic changes except blood pressure decrease at the beginning of CP bypass. It is concluded that high dose fentanyl-oxygen anesthesia was limitedly effective to block the stress of open heart surgery, general anesthesia and CP bypass.
Key Words: Anesthesia; Fentanyl; Open heart surgery; Norepinephrine; Epinephrine
Share :
Facebook Twitter Linked In Line it
METRICS Graph View
  • 0 Crossref
  • 924 View
  • 2 Download


Browse all articles >

Editorial Office
101-3503, Lotte Castle President, 109 Mapo-daero, Mapo-gu, Seoul 04146, Korea
Tel: +82-2-792-5128    Fax: +82-2-792-4089    E-mail: journal@anesthesia.or.kr                

Copyright © 2023 by Korean Society of Anesthesiologists.

Developed in M2PI

Close layer
prev next