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Korean J Anesthesiol > Volume 21(1); 1988 > Article
Korean Journal of Anesthesiology 1988;21(1):1-10.
DOI: https://doi.org/10.4097/kjae.1988.21.1.1   
Effects of Verapamil on the Hemodynamic Responses to Nitroglycerin during Halothane-N2O Anesthesia.
Song Soo Nah, Chan Jin Park, Sung Su Chung
1Department of Anesthesiology, Chonnam National University Medical School, Korea.
2Department of Anesthesiology, Chonnam National University College of Dentistry, Korea.
Hemodynamic variables in 8 verapamil pretreated patients(the verapamil pretreated group) were compared with those in 10 patients without pretreatment(the control group) during nitroglycerin(NTG) induced hypotension under halothane-N2O anesthesis. The results were as follows: 1) In the control group, there were statistically significant decreases in mean arterial pressure (MAP)(25%), pulmonary arterial pressure(PAP)(32%), pulmonary capillary wedge pressure(PCWP)(30%), central venous pressure(CVP)(33%), but the heart rate(HR), cardiac output(CO), cardiac index(CI) and stroke volume index(SVI) remained unchanged. After discontinuance of NTG, all parameters returned to baseline levels. 2) Verapamil alone produced a small decrease in MAP(6%) and CVP(9%), but other hemodynamic values did not change. 3) In the verapamil pretreated group, there were significant decreases in MAP(23%), PAP(30%), PCWP(27%), CVP(20%), SVR(24%) and PVR(31%), but HR, CO, CI, and SVI remained unchanged. 4) These results indicated that verapamil did not significantly affect the hemodynamic response to NTG under halothane-N2O Anesthesis.
Key Words: Verapamil; Nitroglycerime; Hemodynamic responses
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