| Effects of Verapamil on the Hemodynamic Responses to Nitroglycerin during Halothane-N2O Anesthesia. |
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Song Soo Nah, Chan Jin Park, Sung Su Chung |
1Department of Anesthesiology, Chonnam National University Medical School, Korea.
2Department of Anesthesiology, Chonnam National University College of Dentistry, Korea. |
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| Abstract |
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Hemodynamic variables in 8 verapamil pretreated patients(the verapamil pretreated group) were compared with those in 10 patients without pretreatment(the control group) during nitroglycerin(NTG) induced hypotension under halothane-N2O anesthesis. The results were as follows: 1) In the control group, there were statistically significant decreases in mean arterial pressure (MAP)(25%), pulmonary arterial pressure(PAP)(32%), pulmonary capillary wedge pressure(PCWP)(30%), central venous pressure(CVP)(33%), but the heart rate(HR), cardiac output(CO), cardiac index(CI) and stroke volume index(SVI) remained unchanged. After discontinuance of NTG, all parameters returned to baseline levels. 2) Verapamil alone produced a small decrease in MAP(6%) and CVP(9%), but other hemodynamic values did not change. 3) In the verapamil pretreated group, there were significant decreases in MAP(23%), PAP(30%), PCWP(27%), CVP(20%), SVR(24%) and PVR(31%), but HR, CO, CI, and SVI remained unchanged. 4) These results indicated that verapamil did not significantly affect the hemodynamic response to NTG under halothane-N2O Anesthesis. |
| Key Words:
Verapamil; Nitroglycerime; Hemodynamic responses |
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