Korean J Anesthesiol Search

CLOSE


Korean Journal of Anesthesiology 1988;21(4):555-563.
DOI: https://doi.org/10.4097/kjae.1988.21.4.555   
Antihypertensive Effects of Nasal Administration of Nifedipine in Patients Anesthetized with Diethyl - Ether .
Kee Yeong Nam, Young Chul Park, Dong Ho Shin, Seong Wan Baik, Inn Se Kim, Kyoo Sub Chung
1Department of Anesthesiology, St. Benedict Hospital, Pusan, Korea.
2Department of Anesthesiology, College of Medicine, Pusan National University, Pusan, Korea.
Abstract
The effect of intranasal nifedipine drops in 20 randomly chosen patients with diethyl-ether induced hypertension by inhalation anesthesia was observed. Patients were placed in two groups: the first group received intranasal nifedipine at the time of induction and the second group received intranasal nifedipine at the time to skin incision. The change in mean arterial pressure in the first group was not significant, but in the second group, the increase in mean arterial pressure was significant immediately after intranasal administration of nifedipine at the time of skin incision. An increase in pulse rate was noted with the increase in mean arterial pressure and this is thought to result from the stimulation of catecholamine secretion and baroreceptor reflex. Since the difference in mean arterial pressure between the two groups was minimal at ten minutes and twenty minutes after skin incision, it is suggested that the onset of intranasal nifedipine is quite fast. Based on the authors' experience, intranasal administration of nifedipine is very useful in preventing or treating hypertension during inhalation anesthesia using diethyl-ether.
Key Words: Hypertension; intranasal nifedipine; Diethyl-ether


ABOUT
ARTICLE CATEGORY

Browse all articles >

BROWSE ARTICLES
AUTHOR INFORMATION
Editorial Office
101-3503, Lotte Castle President, 109 Mapo-daero, Mapo-gu, Seoul 04146, Korea
Tel: +82-2-792-5128    Fax: +82-2-792-4089    E-mail: journal@anesthesia.or.kr                

Copyright © 2024 by Korean Society of Anesthesiologists.

Developed in M2PI

Close layer
prev next