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Korean Journal of Anesthesiology 1988;21(4):564-568.
DOI: https://doi.org/10.4097/kjae.1988.21.4.564   
The Effects of Atropine and Glycopyrrolate mixed to Neostigmine on Heart Rate in Anesthetized Pediatric Patients .
Keung Sook Lee, Dae Pal Park
Department of Anesthesiology, Yeungnam University, College of Medicine, Taegu, Korea.
Fourty pediatric patients anesthetized with halothane-nitrous oxide-oxygen, who received pancronium for the maintenance of muscular relaxation, were divided into two groups. On anesthesia, in group l, atropine(20ug/kg) and neostigmin(40ug/kg), and in group ll, glycopyrrolate(10ug/kg) and neostigmine(40ug/kg) were injected transvenously. The changes in heart rate and arrythmis were then observed. The results were as follows: 1) The safety and effectiveness of both groups in antagonizing the muscarinic actions of neostigmine were demonstrated. 2) Glycopyrrolate produced a significantly smaller change in heart rate than atropine. 3) In both groups, arrhythmis could not be observed.
Key Words: Pediatric patients; Neostigmine; Glycopyrrolate; Atropine; Heart rate; Neuromuscular blocker


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