Korean Journal of Anesthesiology

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Randomized Controlled Trial
Korean J Anesthesiol. 2008;55(4):452-457.
DOI: https://doi.org/10.4097/kjae.2008.55.4.452
A comparison of the suppression of cough reflex by intravenous lidocaine and remifentanil prior to extubation of the endotracheal tube.
Dong Hwa Kang, Young Whan Kim, Suk Whan Choi, Sang Eun Lee, Se Hun Lim, Jeong Han Lee, Kun Moo Lee, Soon Ho Cheong, Young Kyun Choe, Young Jae Kim, Chee Mahn Shin
Department of Anesthesiology and Pain Medicine, College of Medicine, Inje University, Busan, Korea. anehero@naver.com
Abstract
BACKGROUND
Cough reflex in response to extubation of the endotracheal tube is common; however, the effect of remifentanil on cough reflex is uncertain. Therefore, we evaluated the effect of lidocaine and remifentanil on cough reflex following extubation.
METHODS
Forty adult patients scheduled to undergo elective surgery in two hours were enrolled in this study. All patients received a standard anesthetic protocol. Following surgery, the patients were randomly divided into two groups, Group L (n = 20), which received 1.5 mg/kg of 2% lidocaine intravenously, and Group R (n = 20), which received 0.5 microgram/kg remifentanil intravenously. Treatment was administered immediately after the patients opened their eyes, after which extubation was performed. We then evaluated breath holding and recorded the number of coughs at 5 minutes, 15 minutes and 30 minutes after extubation. In addition, we checked for sore throat 30 minutes after extubation.
RESULTS
The number of coughs was significantly lower in Group R than in Group L at 5 minutes after extubation. However, there was no significant difference in the number of coughs in Group R and Group L at any other times evaluated.
CONCLUSIONS
There are no significant differences in suppression of the cough reflex in response to treatment with lidocaine and remifentanil.

Keywords :cough relex;extubation;lidocaine;remifentanil

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