Korean Journal of Anesthesiology

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Original Article
Korean J Anesthesiol. 2007;53(5):598-601.
DOI: https://doi.org/10.4097/kjae.2007.53.5.598
The Effect of Ondansetron on the Emergence Agitation after Sevoflurane Anesthesia in Pediatric Patients Undergoing Tonsillectomy.
Kun Moo Lee, Dong Hwa Kang, Sang Eun Lee, Young Hwan Kim, Se Hun Lim, Jeong Han Lee, Soon Ho Cheong, Young Kyun Choe, Young Jae Kim, Chee Mahn Shin
Department of Anesthesiology and Pain Medicine, Paik Hospital, College of Medicine, Inje University, Busan, Korea. aneslkm@inje.ac.kr
Abstract
BACKGROUND
Emergence agitation is a common problem after sevoflurane anesthesia in children. Tropisetron, a 5-HT3 antagonist, significantly reduces the incidence of emergence agitation after sevoflurane anesthesia. This study evaluated the effect of ondansetron on emergence agitation after sevoflurane anesthesia in children undergoing a tonsillectomy.
METHODS
Eighty children, aged 3-9 years (ASA physical status I) undergoing tonsillectomy, were randomly enrolled in this study. Group O received 0.1 mg/kg of ondansetron, and group S received 0.1 ml/kg of saline during the operation. Anesthesia was induced with 5 vol% sevoflurane and maintained with 2-2.5 vol% sevoflurane. The agitation score was recorded when they arrived at the postanesthesia care unit, and 10 minutes after that.
RESULTS
The incidence of emergence agitation was 30% in group O and 27.5% in group S at arrival (P = 1.00). Ten minutes after arrival, the incidence was 12.5% in group O and 25% in group S (P = 0.25).
CONCLUSIONS
Ondansetron 0.1 mg/kg does not reduce the incidence of emergence agitation after sevoflurane in children.

Keywords :emergence agitation;ondansetron;pediatric;sevoflurane

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