Korean Journal of Anesthesiology

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Original Article
Korean J Anesthesiol. 2006;50(5):490-494.
DOI: https://doi.org/10.4097/kjae.2006.50.5.490
The Effect of Preoperative Dexamethasone on Profopol Injection Pain, Postoperative Nausea and Vomiting Undergoing Otolaryngology-Head and Neck Surgery.
Cheol Lee, Tai Yo Kim, Yoon Kang Song, Yong Son, Yong Kwan Cheong, Min Soo Kim
Department of Anesthesiology and Pain Medicine, School of Medicine, Wonkwang University, Iksan, Korea. ironyii@wonkwang.ac.kr
Abstract
BACKGROUND
Induction with propofol has a high incidence of pain, as well as postoperative nausea and vomiting (PONV). The aim of this study was to assess the effect of a course of dexamethasone on the pain, postoperative nausea and vomiting associated with a Propofol injection, in patients undergoing otolaryngology-head and neck surgery.
METHODS
One hundred twenty adults, 20-60 years of age, ASA physical status I or II, were allocated to one of two groups. Either dexamethasone 5 ml (8 mg) or saline 5 ml was administered intravenously to each group. After 60 seconds, propofol was injected into the patients' hand veins over a 30 second period and the patient was asked questions regarding the injection pain after 10 seconds. Postoperative nausea, vomiting and post-tonsilectomy pain were recorded in the recovery room (1 h after surgery) and in the hospitalization area (6 h after surgery).
RESULTS
The severity and incidence of pain at the time of the propofol injection, PONV, and the level of post-tonsillectomy pain were significantly lower in the dexamethasone group than in the control group.
CONCLUSIONS
The prophylactic intravenous administration of 8 mg dexamethasone is effective in reducing the severity of pain after a propofol injection and after the tonsillectomy, and decreased the incidence of PONV.

Keywords :dexamethasone;injection pain;nausea;vomiting

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