Korean Journal of Anesthesiology

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Clinical Research Article
Korean J Anesthesiol. 2003;45(1):13-21.
DOI: https://doi.org/10.4097/kjae.2003.45.1.13
The Influences of Clonidine Premedication on the A-lineTM ARX Index and Hemodynamics during Anesthesia Induction with Propofol.
Won Jin Choi, Woo Jae Jeon, Jae Hang Shim, Sang Yoon Cho, Jong Hoon Yeom, Woo Jong Shin, Kyoung Hun Kim
Department of Anesthesiology, College of Medicine, Hanyang University, Seoul, Korea. goldnan@hanyang.ac.kr
Abstract
BACKGROUND
Clonidine, an alpha2-adrenergic receptor agonist, has been shown to have a sedative effect and to suppress hemodynamics when used as a premedicant. We evaluated the change of AEP index and hemodynamics after clonidine premedication and induction with propofol.
METHODS
The study design was a prospective, randomized, double-blind study. 90 patients who were scheduled for elective surgery were randomly assigned in 3 groups (Group 1, 2 and 3). In groups 2 and 3, the patients were administered 2 microgram/kg or 4 microgram/kg of i.v. clonidine 30 minutes before the induction of propofol anesthesia, respectively. We measured A-lineTM ARX index (AAI), systolic blood pressure, mean arterial pressure, diastolic blood pressure and heart rate at the ward; before the administration of clonidine premedication, before induction, just before intubation and 1 minute after endotracheal intubation, and compared these parameters among the 3 groups.
RESULTS
Each dose of clonidine had a suppressive effect before the induction of anesthesia and suppressed hemodynamics successfully during intubation. In groups 2 and 3, the AAI was lower than in group 1 (P < 0.05), but 7 patients had bradycardia and 3 patients had been hypotensive in group 3.
CONCLUSIONS
Intravenous injection of 2 microgram/kg clonidine as a premedicant reduced AAI significantly (P < 0.05) compared to the control group, with good hemodynamic stability. Therefore, we believe that AAI can be used to predict hypnotic state during propofol anesthesia.

Keywords :alpha2-adrenoreceptor agonist;A-lineTM ARX index (AAI);clonidine

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