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Korean J Anesthesiol > Volume 22(4); 1989 > Article
Korean Journal of Anesthesiology 1989;22(4):530-535.
DOI: https://doi.org/10.4097/kjae.1989.22.4.530   
Changes of Circuratory Response during Intubation by Small Dose Fentanyl.
Dong Whan Kim, Jin Hyoung Kwon, Cheong Lee, Kyoung Hun Kim, Dong Ho Lee, Kyo Sang Kim, Jung Kook Suh, Hee Koo Yoo, Ik Sang Seung, Se Ung Chon, Jae Chul Shim
1Department of Anesthesiology, College of Medicine, Hanyang University, Seoul, Korea.
2Department of Anesthesiology, College of Medicine, Soon Chun Hyang University, Eumsung, Korea.
Induction of general anesthesia with tracheal intubation is routine procedure but causes significant tarchycardia and hypertension. Many approaches have been tried to attenuate these circulatory response. The effects of small dose fentanyl on arterial pressure and heart rate increase during intubation were studied in 40 normotensive patients, who were randomly allocated to two groups, receiving saline (Control group) or fentanyl 2ug/kg (Fentanyl group), in a double blind fashion during anesthetic induction with thiopental 5mg/kg. Systolic, diastolic, mean arterial pressure and heart rate were measured and rate pressure product was calculated. All parameters were significantly different between two groups (p<0,05) and control group was significant increase in blood pressure and heart rate compared with pre-induction value but fentanyl group was relatively small changes of blood pressure and heart rate (p<0.01). After tracheal intubation, incresed blood pressure was returned to pre-induction value within two to three minutes in fentanyl group but heart rate was not returned pre-induction value within 5 minutes. Dose of fentanyl that are low enough to cause any side effects of drug itself, no notable side effects were observed during study and recovery.
Key Words: Circulatory response; intubation; Analgesics; small dose fentanyl
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