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Korean Journal of Anesthesiology 1980;13(2):128-134.
DOI: https://doi.org/10.4097/kjae.1980.13.2.128   
Effect of Epidural Morphine on Postoperative Pain and Arterial Blood Gas Values .
Nam Sik Woo, Hee Jeon Lee, Hung Kun Oh
Department of Anesthesiology, Yonsei University College of Medicine, Seoul, Korea.
After the identification by Snyder of specific opiate receptors it the substantia gelatinosa of the posterior horn of the spinal cord, Behar et al. reported that small doses of epidural morphine are effective in treatment of acute and chronic pain. We have administered 3~5 mg of epidural morphine as a single dose with 1.5~2 % lidocaine to 40 patients as a continuous lumber epidural anesthesia and to 20 patients as a single caudal anesthesia. All the patients had remarkable relief of pain and we can confirm that there was no loss of sensation to temperature, touch or pinprick. However the dosage (3. 4 or 5 mg) of morphine administrated did not affect the duration of postoperative pain relief. Arterial blood pressure and heart rate were measured up to 15 minutes after morphine injection at 5 minutes intervals, but were not significantly changed. PaO2, PaCO2 pH and base excess were also not significantly changed.


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