Acute respiratory alkalosis occurring after endoscopic third ventriculostomy -A case report-

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Korean J Anesthesiol. 2010;59(Suppl):S194-S196
Publication date (electronic) : 2010 December 31
doi : https://doi.org/10.4097/kjae.2010.59.S.S194
1Institutes of Health Sciences, Gyeongsang National University School of Medicine, Jinju, Korea.
2Department of Anesthesiology and Pain Medicine, Gyeongsang National University School of Medicine, Jinju, Korea.
Corresponding author: Ju-Tae Sohn, M.D., Department of Anesthesiology and Pain Medicine, Gyeongsang National University School of Medicine, 92, Chiram-dong, Jinju 660-702, Korea. Tel: 82-55-750-8586, Fax: 82-55-750-8142, jtsohn@nongae.gsnu.ac.kr
Received 2009 December 18; Revised 2010 May 03; Accepted 2010 May 26.

Abstract

An endoscopic third ventriculostomy was performed in a 55-year-old man with an obstructive hydrocephalus due to aqueductal stenosis. The vital signs and laboratory studies upon admission were within the normal limits. Anesthesia was maintained with nitrous oxide in oxygen and 6% desflurane. The patient received irrigation with approximately 3,000 ml normal saline during the procedure. Anesthesia and operation were uneventful. However, he developed postoperative hyperventilation in the recovery room, and arterial blood gas analysis revealed acute respiratory alkalosis. We report a rare respiratory alkalosis that occurred after an endoscopic third ventriculostomy.

A third ventriculostomy is common endoscopic procedure, and refers to fenestration of the floor of the third ventricle to create communication between the third ventricle and basilar cisterna [1]. This technique is applied mostly to patients with an obstructive hydrocephalus [1,2]. This form of hydrocephalus results from impaired cerebrospinal fluid (CSF) flow through the Sylvian aqueduct or fourth ventricle outlets. The complications associated with an endoscopic third ventriculostomy include minor or major intraventricular hemorrhage, pneumocephalus, injury to the paraventricular structure (basal ganglia, hypothalamus, brain stem) and cardiopulmonary depression (arrhythmia) [1]. We report a rare respiratory alkalosis [3] which was successfully treated with controlled mechanical ventilation after an endoscopic third ventriculostomy.

Case Report

A 55-year-old man was admitted to the general ward at a Gyeongsang National University Hospital with an obstructive hydrocephalus visualized by brain magnetic resonance imaging. A ventriculoperitoneal shunt had been placed 2 years earlier due to an obstructive hydrocephalus, but the physical examination was within the normal limits with the exception of an upward gaze disturbance. His vital signs were stable. The laboratory studies including a complete blood count, electrocardiogram, liver and renal function tests were within the normal limits. A chest posteroanterior radiography revealed ventriculoperitoneal shunt in place.

The patient was premedicated with midazolam (2.5 mg) and glycopyrrolate (0.2 mg). Anesthesia was induced with 250 mg sodium thiopental and 50 mg rocuronium while he received oxygen (5 L/min) through a face mask. Fiberoptic orotracheal intubation was then accomplished using a reinforced endotracheal tube (internal diameter: 7.5 mm). Anesthesia was maintained with nitrous oxide in oxygen (50% : 50%) and 6 vol% desflurane. The intraoperative end-tidal carbon dioxide tension was maintained within 30-35 mmHg. He received irrigation with approximately 3,000 ml normal saline at room temperature while introducing the neuroendoscope (MINOP neuroendoscopy system, Aesculap, Center Valley, Pennsylvania, USA) with a shaft diameter of 2.7 mm, a maximum infusion rate of 1,000 ml/min and a maximum pumping pressure of 500 mmHg. During the surgical procedure, irrigation fluid was naturally drained and the neuroendoscopic intracranial pressure was not measured because monitoring equipment was unavailable. Two hours after beginning the procedure, his systolic blood pressure and heart rate increased from 100 mmHg to 170 mmHg and from 45-90 beats/min to 100-110 beats/min, respectively. Intravenous hydralazine (10 mg) and esmolol (10 mg) was administered to control the increased blood pressure and heart rate. However, the increased heart rate persisted from 2 hours after beginning the procedure to the end of the operation. Otherwise, the operation and anesthesia were uneventful.

In order to rule out a postoperative hemorrhage, brain computerized tomogram taken immediately after the endoscopic third ventriculostomy revealed the external ventricular drainage catheter and pneumocephalus on the left frontal convexity. The neuromuscular blockade was reversed with 15 mg pyridostigmine and 0.4 mg glycopyrrolate. Although he showed mild confusion, the patient was extubated after confirming adequate voluntary respiration. The patient remained in the recovery room because he showed mild confusion after extubation. Four hours after surgery, the respiratory rate increased to 50-66/min and he showed seizure-like movements. Although administering intravenous diazepam (10 mg), haloperidol (3 mg) and orfil (300 mg) to treat the seizure-like movement, mild seizure-like activity such as myoclonal jerk persisted for 2 hours and was treated successfully with intravenous administration of another 10 mg diazepam used for endotracheal intubation. Arterial blood gas analysis at that time revealed acute respiratory alkalosis (Table 1). The patient was transferred to the intensive care unit. Orotracheal intubation using a direct laryngoscope was then performed with the intravenous administration of 10 mg diazepam, and controlled mechanical ventilation (assist-control mechanical ventilation mode: tidal volume; 500 ml, respiratory rate; 16/min, inspired oxygen fraction; 40%) was applied for 15 hours (Table 1). The hyperventilation was treated successfully with controlled mechanical ventilation. Ventilator weaning was accomplished on the first postoperative day (Table 1). He was transferred to the general ward on the second postoperative day.

Table 1

Arterial Blood Gas Analysis

Discussion

The complication rate for endoscopic third ventriculostomy ranges from 6% to 8%, and is similar to the expected infection rate of a shunt [4]. The complications of an endoscopic third ventriculostomy include cerebrospinal fluid leak, pneumocephalus, ventriculitis, subdural hematoma, injury to the periventricular structures (hypothalamus, basal ganglia and brain stem), bradycardia, asystole, minor bleeding and hypokalemia [2,4].

The etiology of respiratory alkalosis includes hypoxia, parenchymal lung disease, bronchial asthma, drug, mechanical ventilation, central nervous system disorder, metabolic causes and hyperventilation [5]. Respiratory alkalosis associated with hyperventilation was detected in our patient 4 hours after extubation. The floor of the third ventricle is not a membrane but a part of the hypothalamus [4]. Massive or high-speed irrigation with normal saline has been associated with a hypothalamic dysfunction. As the neuroendoscope used in this patient was not equipped with device for a critical setting of infusion rate and pumping pressure, an unchecked maximum infusion rate (1,000 ml/min) and pumping pressure (500 mmHg) which produce a transient increase in pressure inside neuroendoscope may cause a transient injury of periventricular st ructures such as hypothalamus. Late arousal and postoperative confusion are caused by trauma to the sensitive hypothalamic structures [4]. A >30 mmHg pressure inside the endoscope is associated with postoperative morbidity, particularly unexpected delayed recovery [6]. Hypothalamic-mesencephalic dysfunction is associated with hypertension, hyperthermia, and hyperventilation [7]. It is very difficult to determine the causes of hyperventilation observed in this patient. The possible causes are as follows. First, considering the above reports [6,7], hypothalamic dysfunction caused by an unrecognized increased intracranial pressure due to the high-speed irrigation of normal saline during an endoscopic third ventriculostomy may contribute to the hyperventilation observed in the recovery room. A critical setting of infusion rate and pumping pressure during an endoscopic third ventriculostomy might help reduce pressure transferring to periventricular structures. Therefore, we recommend that the neuroendoscopic intracranial pressure be monitored to prevent the complications associated with hypothalamic dysfunctions. Second, this hyperventilation may be partially associated with CSF acidosis induced by normal saline irrigation used during the procedure. The pH of the cerebrospinal fluid is 7.31, whereas that of normal saline is 6.1 [8]. A total of 3,000 ml normal saline used during the endoscopic third ventriculostomy would fill the enlarged lateral and third ventricles with normal saline instead of CSF. After fenestrating the floor of the third ventricle, acidic normal saline in the enlarged lateral and third ventricles drained into the interpuduncular cisterna filled with CSF, which might have led to a more acidic CSF compared to normal CSF. An acidosis of the CSF produces hyperventilation by stimulating the central chemoreceptor. Central lactate production of a meningeal tumor can also cause CSF acidosis, which induces hyperventilation and respiratory alkalosis [9]. The capacity of the male elderly lateral and third ventricle is 35.19 ± 20.35 and 2.63 ± 0.96 ml, respectively [10]. Our findings and those of previous reports [8-10] suggest that the pH in the CSF and arterial blood should be measured simultaneously to confirm the respiratory alkalosis caused by normal saline irrigation-induced CSF acidosis.

The causes of peripheral hyperventilation [5], which include hypoxia, parenchymal lung disease, medication, mechanical ventilation, central nervous system disorder and metabolic disturbance, were excluded by a physical examination and laboratory tests.

In conclusion, central neurogenic hyperventilation was developed in a patient receiving high-speed irrigation and large amount of normal saline (maximum infusion rate of 1000 ml/min and maximum pumping pressure of 500 mmHg) during an endoscopic third ventriculostomy, which may be ascribed to a transient hypothalamic dysfunction and/or acidic CSF. This type of hyperventilation was treated successfully by controlled mechanical ventilation.

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Table 1

Arterial Blood Gas Analysis

Table 1

PaCO2: arterial carbon dioxide tension, PaO2: arterial oxygen tension.