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Korean Journal of Anesthesiology 2008;55(4):446-451.
DOI: https://doi.org/10.4097/kjae.2008.55.4.446   
Maternal and neonatal effects of sevoflurane and desflurane in cesarean section.
In Hwa Lee, Dong Yeon Kim, Rack Kyung Chung, Chi Hyo Kim
Department of Anesthesiology and Pain Medicine, Ewha Womans University School of Medicine, Seoul, Korea. kdyeon@ewha.ac.kr
This study was designed to compare the maternal and neonatal effects of two volatile anesthetic agents, sevoflurane and desflurane during general anesthesia for cesarean section.
Sixty patients undergoing cesarean section were randomly selected and divided into two groups. After induction, sevoflurane (Group S, n = 30) and desflurane (Group D, n = 30) were administered to achieve steady-state end-tidal concentration of 1 vol% and 3 vol%, respectively. The maternal outcomes were evaluated at various time points in terms of hemodynamic changes and bispectral index (BIS). The neonatal characteristics were descripted with Apgar score and umbilical blood gas analysis.
The BIS was lower in Group D than in Group S at 5 and 7 minutes after intubation and at delivery (P < 0.05). The value of BIS is between 40 to 60 in Group D appropriated with anesthetic depth during surgery. Other parameters as well as neonatal outcomes were not different between two groups. Intraoperative awareness of patients were not present at all.
Maternal and neonatal effects were not significantly different between two groups and no adverse effects were seen. Despite of BIS over 60 at some period, maternal recall during surgery were absent postoperatively. Therefore, not only sevoflurane but also desflurane can be used for safe and effective anesthesia in cesarean section.
Key Words: bispectral index; cesarean section; desflurane; general anesthesia; sevoflurane


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