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Korean J Anesthesiol > Volume 15(2); 1982 > Article
Korean Journal of Anesthesiology 1982;15(2):131-138.
DOI: https://doi.org/10.4097/kjae.1982.15.2.131   
Effects of InhaIational Anesthetics an Renal Function in Rabbits .
Jeong Hoi Kim
Department of Anesthesiology, College of Medicine, Jeonbug University, Jeonju, Korea.
In order to investigate the effects of inhalational anesthetics on renal function, small doses of ether or halothane were administered intravenously to rabbits without anesthesia, or disectly injected into the renal artery of the rabbits under urethane anesthesia. The following results were obtained. 1) 1mg/kg of 8% saturated solution of ether did not influence excretion of urine, creatinine and electrolytes, and osmolarity when intravenously administered over 10 minutes. 2) 1 mg/kg of the above solution markedly reduced urine volume, renal blood flow, glomerular filtration rate and excretion of electrolytes such as sodium, potassium,, chloride when directly injected into the renal artery over 10 minutes. 3) 0.5to 1.0% saturated solution of halothane did not influence renal functions when injected either intravenously or directly into the renal artery. 4) Reduced urine volume and sodium excretion were closely related to the decrease in renal blood flow when ether was injected directly into the renal artery. 5) From the above results it is suggested that halothane did not influence renal function while ether had a direct effect on renal function by hemodynamic change in renal circulation.
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