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Korean J Anesthesiol > Volume 57(4); 2009 > Article
Korean Journal of Anesthesiology 2009;57(4):428-433.
DOI: https://doi.org/10.4097/kjae.2009.57.4.428   
Assessment of cerebral oxygen supply-demand balance by near-infrared spectroscopy during induction of anesthesia in patients undergoing coronary artery bypass graft surgery: comparison of midazolam with propofol.
Dae Hee Kim, Young Lan Kwak, Soon Ho Nam, Min Soo Kim, Eun Mi Kim, Jae Kwang Shim
1Department of Anesthesiology and Pain Medicine, Ajou University College of Medicine, Suwon, Korea.
2Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, Korea. aneshim@yuhs.ac.kr
3Anesthesia an Pain Research Institute, Yonsei University College of Medicine, Seoul, Korea.
Near-infrared spectroscopy (NIRS) continuously measures regional cerebral oxygen saturation (rSO2) noninvasively and has been shown to detect even small changes in cerebral oxygen supply-demand balance. Although widely used, only the effect of midazolam on cerebral blood flow has been studied in humans and evidence is lacking about its effect on cerebral metabolic rate. We therefore evaluated the effect of midazolam on cerebral oxygen supply-demand balance with NIRS.
Sixty patients undergoing elective coronary artery bypass graft surgery were randomly allocated into either midazolam (n = 30) or propofol (n = 30) group. rSO2 was recorded before induction while patients were breathing room air as baseline, after pre-oxygenation with 100% oxygen, after administration of either midazolam or propofol, after completion of administration of sufentanil and after tracheal intubation. Hemodynamic variables including cardiac index and mixed venous oxygen saturation were recorded at the same time points.
rSO2 and hemodynamic variables were similar between the groups throughout the study period. After pre-oxygenation, rSO2 significantly increased compared to baseline in each group, and did not show any additional increase after administration of either midazolam or propofol and sufentanil in both groups.
Midazolam preserves cerebral blood flow-metabolism coupling to a similar degree to propofol as assessed by near infrared spectroscopy.
Key Words: Cerebral oxygen supply-demand balance; Coronary artery bypass graft surgery; Midazolam; Near-infrared spectroscopy; Propofol
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