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Korean Journal of Anesthesiology 2009;57(6):719-722.
DOI: https://doi.org/10.4097/kjae.2009.57.6.719   
The effects of calcium channel blockers pretreatment on blood potassium level after the administration of succinylcholine in hypertensive patients.
Ji Hyun Ko, Tae Hun An
Department of Anesthesiology and Pain Medicine, School of Medicine, Chosun University, Gwangju, Korea. than@chosun.ac.kr
The aim of the present study was to evaluate whether calcium channel blockers pretreatment increase blood potassium level after the administration of succinylcholine in hypertensive patients. METHODS: Eighty hypertensive patients were randomly divided into four groups: group I (saline, n = 20), group II (nicardipine 30 microg/kg, n = 20), group III (diltiazem 0.2 mg/kg, n = 20), group IV (verapamil 0.1 mg/kg, n = 20). The patients had been taking antihypertensive drugs regularly and their blood pressures were well controlled. Anesthesia was induced with thiopental sodium 5 mg/kg and tracheal intubation was facilitated with succinylcholine 1 mg/kg. Saline, nicardipine, diltiazem, and verapamil were administered two minutes before injection of succinylcholine in group I, II, III, and IV, respectively. Blood potassium level was measured prior to induction and 1, 3, 5, 10, 15, 30, 45, 60, 75, 90 minutes after administration of succinylcholine. RESULTS: Blood potassium levels at 5, 10, 15, and 30 minutes after the administration of succinylcholine were significantly increased compared with baseline values in all groups (P < 0.05). Blood potassium level was not different significantly among four groups at all times. CONCLUSIONS: Calcium channel blockers pretreatment did not increase blood potassium level after the administration of succinylcholine. We concluded that succinylcholine and calcium channel blocker can be used safely together in hypertensive patients.
Key Words: Calcium channel blockers; Hypertensive patients; Potassium; Succinylcholine


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