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Korean Journal of Anesthesiology 2007;53(5):598-601.
DOI: https://doi.org/10.4097/kjae.2007.53.5.598   
The Effect of Ondansetron on the Emergence Agitation after Sevoflurane Anesthesia in Pediatric Patients Undergoing Tonsillectomy.
Kun Moo Lee, Dong Hwa Kang, Sang Eun Lee, Young Hwan Kim, Se Hun Lim, Jeong Han Lee, Soon Ho Cheong, Young Kyun Choe, Young Jae Kim, Chee Mahn Shin
Department of Anesthesiology and Pain Medicine, Paik Hospital, College of Medicine, Inje University, Busan, Korea. aneslkm@inje.ac.kr
Emergence agitation is a common problem after sevoflurane anesthesia in children. Tropisetron, a 5-HT3 antagonist, significantly reduces the incidence of emergence agitation after sevoflurane anesthesia. This study evaluated the effect of ondansetron on emergence agitation after sevoflurane anesthesia in children undergoing a tonsillectomy.
Eighty children, aged 3-9 years (ASA physical status I) undergoing tonsillectomy, were randomly enrolled in this study. Group O received 0.1 mg/kg of ondansetron, and group S received 0.1 ml/kg of saline during the operation. Anesthesia was induced with 5 vol% sevoflurane and maintained with 2-2.5 vol% sevoflurane. The agitation score was recorded when they arrived at the postanesthesia care unit, and 10 minutes after that.
The incidence of emergence agitation was 30% in group O and 27.5% in group S at arrival (P = 1.00). Ten minutes after arrival, the incidence was 12.5% in group O and 25% in group S (P = 0.25).
Ondansetron 0.1 mg/kg does not reduce the incidence of emergence agitation after sevoflurane in children.
Key Words: emergence agitation; ondansetron; pediatric; sevoflurane


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