| Negative-pressure Pulmonary Edema by Doxapram-induced Larygospasm: A case report. |
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Jung Kook Suh, Jong Hoon Yeom, Dong Jun Bae |
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Department of Anesthesiology and Pain Medicine, School of Medicine, Hanyang University, Seoul, Korea. yeomjh@hanyang.ac.kr |
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| Abstract |
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Doxapram is a peripheral and central respiratory stimulant, producing an increase in tidal volume and a slight increase in respiratory rate. It can temporarily overcome drug-induced respiratory and central nervous system depression, including that seen immediately postoperatively.
However, it can also cause side effects, including laryngospasm and vomiting postoperatively. Doxapram-induced laryngospasm causes the increased respiratory efforts to induce more negative pleural pressure, thus causing a negative-pressure pulmonary edema.Therefore, doxapram should not be used if signs of upper airway obstruction are present. |
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