Korean J Anesthesiol Search

CLOSE


Korean J Anesthesiol > Volume 54(4); 2008 > Article
Korean Journal of Anesthesiology 2008;54(4):373-377.
DOI: https://doi.org/10.4097/kjae.2008.54.4.373   
The Influence of a Muscle Relaxant on Bispectral Index during the Propofol Induction of Anesthesia.
Yun Chul Shin, Soon Im Kim, Si Young Ok, Sun Chong Kim
Department of Anesthesiology and Pain Medicine, Soonchunhyang University College of Medicine, Seoul, Korea. soonnim@hosp.sch.ac.kr
Abstract
BACKGROUND
Although neuromuscular blockade can influence the bispectral index (BIS) during anesthesia, there have been contradictory reports regarding its effects. The purpose of this study was to investigate whether a muscle relaxant affected the level of BIS during propofol anesthesia.
METHODS
Forty-eight healthy patients undergoing elective surgery under general anesthesia were enrolled in this prospective, randomized, double-blind study. All patients received an effect-site targeted concentration of propofol via a TCI system that was titrated until loss of consciousness occurred. The patients then received either an injection of vecuronium (relaxant group, n = 24) or normal saline as a placebo (placebo group, n = 24) at 3 minutes after loss of consciousness. The BIS and electromyogram (EMG) activity were recorded from anesthetic induction to 4 minutes after injection of the vecuronium or placebo.
RESULTS
The BIS significantly decreased after injection in both groups (P < 0.05), however, the decrease in the BIS was larger in the relaxant group than in the placebo group (P < 0.05). The decrease of EMG activity was not significantly different between the two groups after administration of vecuronium or placebo.
CONCLUSIONS
During propofol induction of anesthesia, a muscle relaxant decreased BIS significantly without decreasing the EMG activity.
Key Words: bispectral index; electromyogram activity; muscle relaxant; propofol
TOOLS
Share :
Facebook Twitter Linked In Line it
METRICS Graph View
  • 3 Crossref
  •    
  • 1,141 View
  • 11 Download


ABOUT
ARTICLE CATEGORY

Browse all articles >

BROWSE ARTICLES
AUTHOR INFORMATION
Editorial Office
101-3503, Lotte Castle President, 109 Mapo-daero, Mapo-gu, Seoul 04146, Korea
Tel: +82-2-792-5128    Fax: +82-2-792-4089    E-mail: journal@anesthesia.or.kr                

Copyright © 2022 by Korean Society of Anesthesiologists.

Developed in M2PI

Close layer
prev next