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Korean Journal of Anesthesiology 2005;48(5):479-482.
DOI: https://doi.org/10.4097/kjae.2005.48.5.479   
The Effect of Ketamine for Pain on Rocuronium Injection Pain.
Hae Wone Chang, Seung Ryong Kim, Yoon Ki Lee
Department of Anesthesiology, College of Medicine, The Catholic University of Korea, Seoul, Korea. yklee@catholic.ac.kr
Abstract
BACKGROUND
Rocuronium can cause pain on injection in awake patients. We compared the effect of ketamine at three different small doses (0.1 mg/kg, 0.2 mg/kg, 0.3 mg/kg) and saline (placebo) for reducing pain on injection in awake patients.
METHODS
80 patients (aged 19-63 yr) scheduled for elective surgery were randomized to four groups in double-blind manner. Patients received the study drug intravenously, with venous occlusion for 20 seconds, followed by rocuronium 0.6 mg/kg into the dorsal vein over 10 seconds. Patient's response torocuronium injection was graded by four-point verbal rating scale.
RESULTS
The incidence of pain was significantly less in patients receiving ketamine 0.3 mg/kg (55%) than in patients receiving saline (85%)(P < 0.05). But, No difference was found between ketamine 0.1 mg/kg, 0.2 mg/kg and saline groups. The pain score was significantly less in patients receiving ketamine 0.2 mg/kg and 0.3 mg/kg than in patients receving saline (P < 0.05).
CONCLUSIONS
We concluded that pretreatment of ketamine 0.3 mg/kg with venous occlu-sion for 20 seconds, effectively decreases the incidence of pain caused by rocuronium injection.
Key Words: ketamine; pain; rocuronium


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