Korean J Anesthesiol Search

CLOSE


Korean J Anesthesiol > Volume 49(5); 2005 > Article
Korean Journal of Anesthesiology 2005;49(5):612-616.
DOI: https://doi.org/10.4097/kjae.2005.49.5.612   
Effects of EDTA (Ethylene Diamine Tetra Acetic Acid) in Propofol on Serum Electrolyte, BUN and Creatinine during Long Time Neurosurgical Operation.
Jun Seog Lee, Jong Hae Kim, Bong Il Kim
Department of Anesthesiology and Pain Medicine, School of Medicine, Catholic University of Daegu, Daegu, Korea. bikim@cu.ac.kr
Abstract
BACKGROUND
EDTA was added to the formulation of propofol to inhibit microbial growth due to accidental extrinsic contamination. This study was conducted to determine whether the EDTA in the propofol would affect the ionized calcium homeostasis, other electrolyte balance, blood urea nitrogen (BUN) and creatinine (Cr) in long time craniotomy patients.
METHODS
Forty two patients undergoing surgery for clipping of a cerebral aneurysm were randomly assigned to receive either propofol without EDTA (propofol group; n = 20), or propofol with EDTA (propofol EDTA group; n = 22). The ionized calcium, total calcium, total magnesium, phosphate, potassium, sodium, BUN and Cr in the blood were measured at before anesthetic induction, 4 hours after induction and 1 hour after the operation.
RESULTS
There were no significant differences in the ionized calcium, other electrolytes, BUN and Cr between the two groups. CONCLUSIONS: The addition of EDTA into propofol appears to have no significant effects on the electrolyte balance, BUN and Cr concentration.
Key Words: BUN; calcium; craniotomy; creatinine; ethylene diaminetetraacetic acid; propofol
TOOLS
Share :
Facebook Twitter Linked In Line it
METRICS Graph View
  • 0 Crossref
  •    
  • 1,204 View
  • 18 Download


ABOUT
ARTICLE CATEGORY

Browse all articles >

BROWSE ARTICLES
AUTHOR INFORMATION
Editorial Office
101-3503, Lotte Castle President, 109 Mapo-daero, Mapo-gu, Seoul 04146, Korea
Tel: +82-2-792-5128    Fax: +82-2-792-4089    E-mail: journal@anesthesia.or.kr                

Copyright © 2023 by Korean Society of Anesthesiologists.

Developed in M2PI

Close layer
prev next