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Korean Journal of Anesthesiology 2005;49(5):671-678.
DOI: https://doi.org/10.4097/kjae.2005.49.5.671   
Effects of Lidocaine and Propofol on Production of Interleukin (IL)-2, IL-4, and Nitric Oxide in Mice.
Su Ryoung Chung, Jun Young Kim, Kwang Hyeok Kim, Tae Ho Chang
1Department of Anesthesiology and Pain Medicine, Kosin University School of Medicine, Busan, Korea. JDCOH@ns.kosinmed.or.kr
2Department of Microbiology, Kosin University School of Medicine, Busan, Korea.
3Department of Internal Medicine, Wallace Memorial Baptist Hospital, Busan, Korea.
The possibility that anesthesia may alter the course of an infection has been under consideration for more a century. Alterations have been found in every component of the immune response during anesthesia and surgery. In this work, we have investigated the effect of lidocaine and propofol on interleukin-2 (IL-2), interleukin-4 (IL-4), and nitric oxide (NO) production in mice.
The culture supernatants of splenocytes exposed with anesthetics and lipopolysaccharide (LPS), or sera from mice injected with these agents were harvested to assay IL-2, IL-4, and NO.
We detected that IL-2 productions of splenocytes culture supernatants and mice sera after exposure with lidocaine or propofol were decreased while IL-4 productions were increased. In addition, NO of mice sera was increased after lidocaine or propofol exposures.
These findings suggest that lidocaine and propofol interfere with IL-2, IL-4, and NO production. This may explain the clinically well-recognized disturbance of human immunity after surgery and anesthesia.
Key Words: IL-2; IL-4; lidocaine; nitric oxide; propofol


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