| The Effects of Preoperative Vaginal Misoprostol on Gastric Contents. |
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Jeong Yeon Hong, Myoung Jun Kim |
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Department of Anesthesiology and Pain Medicine, Cheil General Hospital and Women's Health Center, Sungkyunkwan University School of Medicine, Seoul, Korea. jenyhongg@hanmail.net |
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| Abstract |
BACKGROUND
The aim of this study was to evaluate the effect of vaginal misoprostol for operative hysteroscopy on preoperative gastric contents and the risk of acid aspiration pneumonitis.
METHODS
Sixty-five patients undergoing operative hysteroscopy who received prophylactic vaginal misoprostol 200 microgram were assigned to the misoprostol group, and sixty-five gynecologic patients without premedication were assigned to the control group. After preoxygenation, a 14-F multiorifice nasogastric tube was inserted for direct aspiration under target-controlled propofol sedation.
RESULTS
The mean pH value of gastric fluid was significantly higher in the misoprostol group (2.7 +/- 1.0) than the control group (1.9 +/- 0.7). The mean aspirated volume was (ml) 15.3 +/- 7.4 in the misoprostol group and 16.8 +/- 6.9 in the control group (P > 0.05). There were significantly less patients at high-risk (gastric fluid volumes > 25 ml and pH < 2.5) in the misoprostol group (8/65, 12.3%) than in the control group (18/65, 27.7%).
Prophylactic vaginal misoprostol increases the preoperative gastric pH and reduces the number of at high-risk of acid aspiration pneumonitis.
CONCLUSIONS
Therefore, vaginal misoprostol for outpatient hysteroscopy may have preventive effect on the acid aspiration pneumonitis. |
| Key Words:
aspiration pneumonitis; gastric content; outpatient surgery; prostaglandins E |
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