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Korean J Anesthesiol > Volume 51(4); 2006 > Article
Korean Journal of Anesthesiology 2006;51(4):395-399.
DOI: https://doi.org/10.4097/kjae.2006.51.4.395   
The Effect of H1-Receptor Antagonist on Hemodynamic Change during Anesthesia.
Tae Soo Hahm, Chung Soo Kim, Myong Shin Koo, Byung Seop Shin, Hee Youn Hwang, Sang Min Lee, Hyun Sung Cho
Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. hscho@smc.samsung.co.kr
Abstract
baseline for safe use of a drug.
RESULTS
SVR and PVR failed to show statistically significant changes. Heart rates were increased only at 2 minute after administration of chlorpheniramine maleate. Blood pressures were increased but returned to basal level within 4 minutes. Cardiac output showed statistically significant increase until 8 minutes. However, the changes of hemodynamic values were maintained within 20% of basal levels.
CONCLUSIONS
Chlorpheniramine maleate is observed to cause statistically significant hemodynamic change after intravenous administration during anesthesia. But the changes were within 20% of basal levels, and we can safely use chlorpheniramine maleate 8 mg IV in the view of hemodynamic changes.
Key Words: antihistamine; chlorpheniramine maleate; hemodynamic change


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