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Korean J Anesthesiol > Volume 51(4); 2006 > Article
Korean Journal of Anesthesiology 2006;51(4):455-462.
DOI: https://doi.org/10.4097/kjae.2006.51.4.455   
Inhibiting Effect of Amiodarone to Protective Action against Ischemia/Reperfusion Injury Induced by Ischemic Preconditioning.
Eun Hye Koo, Chung Guk Park, Sang Ho Lim, Young Cheol Park
Department of Anesthesiology and Pain Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea. negul88@empal.com
odarone. Isovolumetric left ventricular end systolic pressure (LVESP), left ventricular end diastolic pressure (LVEDP), dP/dtMAX and heart rate were measured.
Group II showed more recovered LVESP, less developed ventricular stiffness, more preserved coronary effluent flow, earlier termination of arrhythmia and smaller infarct size than Group I. Group III showed preserved LVESP and dP/dtMAX, less developed ventricular stiffness, shortest arrhythmia sustaining time, smallest infarct size among all groups. These myocardial protective effects were abolished in Group IV.
We observed that IPC and amiodarone administration, each has myocardial protective effects against myocardial ischemia, but when they are dealt at the same time, their beneficial effects diminished.
Key Words: amiodarone; ischemic preconditioning; isolated heart; myocardial protection; reperfusion arrhythmia


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