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Korean Journal of Anesthesiology 1978;11(4):324-328.
DOI: https://doi.org/10.4097/kjae.1978.11.4.324   
The Influence of Gallamine , d-Tubocurarine and Pancuronium on Intracranial Pressure and Blood Pressure of Rabbits .
In Ho Ha, Won Tae Kim
Department of Anesthesiology, Chonnam University Medical School, Kwangju, Korea.
Arterial pressure increased from normal to 80~90 mrn Hg, 90~100 mm Hg & 110 ~130 mmHg when the intracrania1 pressure was mechanically elevated to 20~40, mm Hg, 50~70 mm Hg & 90~l00mmHg respectively, while rabbits (average 3kg) were anesthetized with subcuttneous urethane, (1gm/kg), In these circumstances, there was no specific change in the intracranial pressure, or arterial pressure between two groups when one was given intravenous 5mg/kg of gallamine and the other 0. 5mg /kg of intravenous pancuronium. But in a group given 1mg/ kg of d-tubocurarine, arterial pressure decreased significantly, while intracranial pressure was not changed particularly arterial pressure decreased more significantly when the intracranial pressure was increased to 90~100 mm Hg, resulting in an initial arterial pressure of 110~130 mm Hg. Therefore the authors recommend. d-tubocurarine as the agent of choice among these three non-depolarizing muscle relaxants for induction and maintpnance of anesthesia in patients with elevated intracranial pressure pre-operatively.
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