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Korean Journal of Anesthesiology 1984;17(1):17-26.
DOI: https://doi.org/10.4097/kjae.1984.17.1.17   
The Clinical Comparative Stndy on Liver Function with Enflurane and Halothane Anesthetics.
Jung Kook Suh, Jae Chul Shim, Yu Jae Kim, Chang Woo Chung, Gui Bin Kang, Young Hee Hwang, Hee Koo Yoo, Dong Ho Park, Byung Tae Suh, Wan Sik Kim
Department of Anesthesiology, Hanyang University, College of Medicine, Seoul, Korea.
Halothane was introduced in 1956. It has been used worldwidely as a relatively safe inhalation anesthetic but it is generally accepted that it can cause decrease of liver function. But the causative factor has not yet been pinpointed. Enflurane also seems to decrease liver function but the exact cause is not yet known. In order to study the effects of enflurane and halothane on liver function, we used 10 cases of spinal anesthesia as a control group, and 20 cases each of enflurane and halothane anesthesia respectively as experimental group. We then checked serum GOT, GPT, total bilirubin, alkaline phosphatase, and eosinophil count in peripheral venous blood before oeration and 6 days after operation and looked for the existence of high fever of more than 39 degrees C 3 days postoperatively. The results are as follows: 1) We found statistical significant change of serum GOT, GPT, total billirubin alkaline phosphatase and eosinophil count in spinal, enflurane, or halothane anesthesia beofre and after operation. There was no statistically significance between the control and experimental groups. 2) No patient developed high fever of more than 39 degrees C until 3 days after anesthesia in any group. 3) No significant change of mean arterial blood pressure was observed before and during anesthesia in each group. In this study no definite conclusion that enflurane and halothane might have affected the liver function.


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