Korean J Anesthesiol Search


Korean J Anesthesiol > Volume 47(5); 2004 > Article
Korean Journal of Anesthesiology 2004;47(5):667-670.
DOI: https://doi.org/10.4097/kjae.2004.47.5.667   
Is it Safe to Use Target-Controlled Propofol Infusion with DiprifusorTM for Children of School Age?
Jong In Han, Hee Seung Lee
Department of Anesthesiology and Pain Medicine, College of Medicine, Ewha Womans University, Seoul, Korea. hanji@ewha.ac.kr
A commercially available target-controlled propofol infusion system, the 'Diprifusor'TM is used for the induction and maintenance of anesthesia in adults, not in children because the pharmacokinetics of propofol in children. We wondered whether it is safe to use the 'Diprifusor'TM in children weighing over 30 kg in clinical practice? METHODS: Twenty unpremedicated children (8-15 yr, group 1) and sixty five unpremedicated adults (16-65 yr, group 2) scheduled for elective surgery were enrolled. After intravenous injection of fentanyl 1microgram/kg, a propofol infusion was started at a target concentration of 4microgram/ml using a 'Diprifusor'TM. We recorded the time to loss of eyelash reflex and effect site concentration at the time of loss of consciousness. Anesthesia was maintained with propofol-fentanyl-50% N2O-rocuronium. We also checked the effect site concentration at the time of eye opening to verbal command.
The effect site concentrations at loss of eyelash reflex were 1.19 +/- 0.66microgram/ml (group 1) and 0.96 +/- 0.55microgram/ml (group 2), and these were not significantly different between the two groups. But the effect site concentrations at eye opening were 1.66 +/- 0.38microgram/ml (group 1) and 1.47 +/- 0.32microgram/ml (group 2) which were significantly different (P <0.05).
'Diprifusor'TM can be used safely in children weighing over 30 kg with a similar effect site concentration at loss of eyelash reflex as adults, but the effect site concentration at eye opening in children is slightly higher than that of adults.
Key Words: children; effect site concentration; target-controlled propofol anesthesia
Share :
Facebook Twitter Linked In Line it
METRICS Graph View
  • 1 Crossref
  • 767 View
  • 3 Download


Browse all articles >

Editorial Office
101-3503, Lotte Castle President, 109 Mapo-daero, Mapo-gu, Seoul 04146, Korea
Tel: +82-2-792-5128    Fax: +82-2-792-4089    E-mail: journal@anesthesia.or.kr                

Copyright © 2022 by Korean Society of Anesthesiologists.

Developed in M2PI

Close layer
prev next