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Korean Journal of Anesthesiology 2001;41(6):S33-S38.
DOI: https://doi.org/10.4097/kjae.2001.41.6.S33   
The Potentiation of the Analgesic Effect of Intrathecally Coadministered Magnesium Sulphate and Bupivacaine in Duration of Sensory Blockade in Rats.
Jae Chan Choi, Kyung Bong Yoon, Jin Soo Kim, Soon Yul Kim, Kwang Ho Lee, Young Bok Lee, Hyun Kyo Lim, Eun Sung Jun
1Department of Anesthesiology, Yonsei University Wonju College of Medicine, Korea. hklim@wonju.yonsei.ac.kr
2Department of Anesthesiology, Ajou University School of Medicine, Suwon, Korea.
Based on previously reported articles, magnesium sulphate seemed to cause a motor paralysis, but not complete analgesia when administered intrathecally alone, but is likely to have a partial analgesic effect. Accordingly, we tested a hypothesis that magnesium sulphate might potentiate the analgesic effect when coadministered intrathecally with bupivacaine.
Eighteen male Sprague-Dawley rats were allocated into three groups of six animals each. The duration of sensory blockade was determined by observing the period when the animal did not vocalize and/or withdraw (struggle) while forceps-pinch tests were applied to a hindlimb paw. The six animals in each of the following three groups were injected intrathecally with 0.03 ml of the different test substances: (group 1) 16.7% magnesium sulphate {50% magnesium sulphate (0.01 ml) + 0.9% sodium chloride (0.02 ml)}; (group 2) 50% magnesium sulphate (0.01 ml) + 0.5% bupivacaine (0.02 ml); (group 3) 0.33% bupivacaine {0.5% bupivacaine (0.02 ml) + 0.9% sodium chloride (0.01 ml)}.
Sensory blockade in the hindlimbs was observed only in group 2 and lasted for 12 to 14 minutes, while there were no sensory blockades in group 1 and group 3.
Magnesium sulphate potentiated the analgesic effect of bupivacaine when coadministered intrathecally with bupivacaine in rats. These results suggest that intrathecal administration of magnesium sulphate may be a useful adjunct to spinal bupivacaine anesthesia.
Key Words: Anesthetic techniques: intrathecal; Pharmacology: bupivacaine; magnesium sulphate


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