| Effects of Spinal Cord Stimulation and Adenosine on Responsiveness of Dorsal Horn Neurons in Neuropathic Rats. |
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Young Jin Lim, Sang Chul Lee, Dong Kwan Kim, Jun Kim, Yong Chul Kim |
1Department of Anesthesiology, Seoul National University College of Medicine, Seoul, Korea. sangclee@snu.ac.kr
2Department of Physiology, Seoul National University College of Medicine, Seoul, Korea. |
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| Abstract |
BACKGROUND
The aim of the present study was to investigate the effect of spinal cord stimulation (SCS) on the electrically evoked responses of the dorsal horn neuron. An additional aim was to examine whether adenosine receptor activation is involved in the effects of SCS.
METHODS
SCS was performed in a rat with a selective spinal nerve (L5/L6) ligation. Adenosine receptor antagonist, theophylline, was administered intraperitoneally after SCS.
Extracellular recordings were made from dorsal horn neurons receiving C- and A-fiber input from the ipsilateral hindpaw.
Neuronal responses were elicited by supramaximal electrical stimulation, given in the sciatic nerve.
RESULTS
Following intraperitoneal administration of theophylline (50 mg/kg), the decreased C-fiber evoked responses were by SCS suppression restored to a pre-SCS level. SCS and theophylline did not produce any significant change in the A-fiber evoked response.
CONCLUSIONS
These results indicate that C-fiber evoked responses are inhibited in preference to A-fiber evoked responses by SCS, and that adenosine-dependent mechanisms may be involved in the resulting SCS effect. |
| Key Words:
C-fiber; spinal cord stimulation; theophylline |
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