| Effects of Etomidate and Propofol on the Calcium Current in the Rat Myocytes. |
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Joung Uk Kim, In Cheol Choi, Seung Woo Ku, Won Tae Kim, Sung Min Han, So Young Lee, Eun Ju Lee |
1Department of Anesthesiology, College of Medicine, University of Ulsan, Korea.
2Department of Anesthesiology, Gachon Medical College, Gil Medical Center, Korea. |
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| Abstract |
BACKGROUND
Cardiovascular instability after induction of intravenous anesthetics may be explained partly by direct negative inotropic effects. We studied the effects of etomidate and propofol on the inward calcium currents (ICa) of rat ventricular myocytes using the whole-cell voltage-clamp technique.
METHODS
ICa was elicited by progressively depolarizing cells from -40 to -50 mV. The peak amplitude of ICa was measured before, during and after the administration of equimolar concentrations of etomidate and propofol.
RESULTS
Exposure to etomidate and propofol produced a concentration-dependent inhibition of ICa.; 1, 10, 100 and 300 micrometer of etomidate decreased the peak ICa (mean +/- SEM) by 14.5 +/- 6.3, 25.9 +/- 9.4, 31.9 +/- 12.1, 42.5 +/- 8.8% and 1, 10, 100 and 300 micrometer of propofol decreased the peak ICa by 15.7 +/-3.4, 21.3 +/-2.5, 59.2 +/-2.0, 69.9 +/-2.8%, respectively.
COCLUSIONS: These results suggest that etomidate and propofol have a direct negative inotropic effect via inhibition of inward calcium currents in rat ventricular myocytes. |
| Key Words:
Anesthetics, intravenous: propofol; etomidate; Animal: rat; Cells: myocyte; Ion: calcium |
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