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Korean J Anesthesiol > Volume 39(2); 2000 > Article
Korean Journal of Anesthesiology 2000;39(2):177-182.
DOI: https://doi.org/10.4097/kjae.2000.39.2.177   
The Influence of Anesthetic Technique on the Responses of White Blood Cells and Interleukin-6 in Patients Undergoing Low Abdominal Surgery.
Myung Hee Kim, Kyung Im Lim
1Department of Anesthesiology, Samsung Medical Center Sungkyunkwan University School of Medicine, Seoul, Korea.
2Department of Anesthesiology, Sungkyunkwan University School of Medicine, Seoul, Korea.
Surgical trauma and anesthesia are associated with postoperative immune suppression. Alterations in immune response have been suggested in the same surgery, according to anesthetic techniques. Therefore, this study was conducted to investigate whether regional anesthesia or premedication with clonidine change postoperative circulating neutrophils, lymphocytes and monocytes, and interleukin 6 (IL-6) responses.
Thirty patients undergoing elective low abdominal surgery were randomly divided into 3 groups: the control group and spinal group received no premedication and the clonidine group received general anesthesia with clonidine premedication. Blood samples were obtained to measure subpopulations of white blood cells (WBC) and IL-6 at pre-induction, immediately after the operation, and 24 h after incision.
Increase in total WBC and percentage of neutrophils, decrease in percentage of lymphocytes and monocytes, and increase in IL-6 levels were significant after surgery, compared to the baseline values within the three groups. However, no significant differences of subsets of WBC and IL-6 level were seen among the groups throughout the study periods.
Anesthetic technique did not influence the levels of circulating WBC and IL-6.
Key Words: Anesthetic technique, general: spinal; Immune response, interleukin-6: white blood cells; Pharmacology: clonidine
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