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Korean J Anesthesiol > Volume 40(3); 2001 > Article
Korean Journal of Anesthesiology 2001;40(3):359-363.
DOI: https://doi.org/10.4097/kjae.2001.40.3.359   
The Effect of Fentanyl and Ketorolac in Intravenous Patient-Controlled Analgesia on Postoperative Nausea and Vomiting and the Effect of Prophylactic Ondansetron.
Jong Hoon Yeom, Sang Yoon Cho, Woo Jong Shin, Gyu Jeong Noh, Dong Ho Lee, Dong Won Kim, Jong Hun Jun, Jae Chol Shim, Jung Kook Suh, Hee Koo Yoo
Department of Anesthesiology, School of Medicine, Hanyang University, Seoul, Korea.
Abstract
BACKGROUND
This study was performed to assess the effect of fentanyl and ketorolac in intravenous patient-controlled analgesia (IV-PCA) on postoperative nausea and vomiting and the antiemetic effect of prophylactic ondansetron after a total abdominal hysterectomy.
METHODS
Of 115 women having general anesthesia for a total abdominal hysterectomy, a non-PCA group (n = 52) didn't receive IV-PCA and a PCA group (n = 39) and ondansetron group (n = 24) received IV fentanyl 1 - 1.5 microgram/kg and IM ketorolac 30 mg as a loading dose and IV-PCA with a mixture of 60 ml with fentanyl 25 - 30 microgram/kg and ketorolac 4 - 5 mg/kg. In addition, the ondansetron group received IV ondansetron 4 mg before an IV-PCA was started. We assessed nausea, vomiting and the need for rescue antiemetics during the first 24 hours postoperation.
RESULTS
During the first 24 hours postoperation, there were no significant differences in the incidence of nausea, vomiting and the need for rescue antiemetics among the groups.
CONCLUSIONS
Intravenous patient-controlled analgesia with fentanyl and ketorolac didn't increase postoperative nausea, vomiting and the need for rescue antiemetics during the first 24 hours postoperation. Also, prophylactic ondansetron didn't significantly reduce the chance of postoperative nausea, vomiting and rescue antiementics.
Key Words: Analgesia: patient-controlled; Pharmacology: fentanyl; ketorolac; ondansetron; Vomiting: nausea; postoperative
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