Korean J Anesthesiol Search

CLOSE


Korean J Anesthesiol > Volume 40(3); 2001 > Article
Korean Journal of Anesthesiology 2001;40(3):389-396.
DOI: https://doi.org/10.4097/kjae.2001.40.3.389   
The Effect of Preemptive Local Infiltration of Lidocaine and Gabapentin on Postoperative Pain in Rats.
Hae Kyu Kim, Hyun Sub Lee, Inn Se Kim, Seong Wan Baik, Jae Young Kwon, Sang Uk Shin
Department of Anesthesiology, College of Medicine, Pusan National University, Busan, Korea.
Abstract
BACKGROUND
Preemptive analgesia may improve postoperative antinociceptive treatment that prevents the development of central sensitization which contributes to post-injury pain hypersensitivity. However, beneficial effects of preemptive analgesia appear controversial. The purpose of this study was to examine the effect of pre- and post-incisional local infiltration of lidocaine and gabapentin on incisional pain in rats.
METHODS
Thirty five male rats were divided into 7 groups; control group (n = 5), pre-lidocaine infiltration group (n = 5), post-lidocaine infiltration group (n = 5), pre-gabapentin 10 mg infiltration group (n = 5), post-gabapentin 10 mg infiltration group (n = 5), pre-gabapentin 30 mg infiltration group (n = 5), and post-gabapentin 30 mg infiltration group (n = 5). To evaluate postoperative mechanical hyperalgesia in injured feet, withdrawal thresholds were measured by calibrated von Frey filaments at 2 hrs, 1, 2, 3, 4, and 5 days after an incision.
RESULTS
The pre-lidocaine infiltration group shows better analgesic effects than post-lidocaine infiltration group until postoperative day 1 (P < 0.05). The gabapentin infiltration groups were effective in postoperative pain management but there were no significant differences between pre- and post- incisional treatment.
CONCLUSIONS
A preemptive lidocaine injection has a good analgesic effect on incisional pain. Gabapentin also has a good analgesic effect on incisional pain.
Key Words: Analgesia: preemptive; Anesthetics, local: lidocaine; Animals: rats; Anticonvulsants: gabapentin
TOOLS
Share :
Facebook Twitter Linked In Line it
METRICS Graph View
  • 0 Crossref
  •    
  • 909 View
  • 4 Download


ABOUT
ARTICLE CATEGORY

Browse all articles >

BROWSE ARTICLES
AUTHOR INFORMATION
Editorial Office
101-3503, Lotte Castle President, 109 Mapo-daero, Mapo-gu, Seoul 04146, Korea
Tel: +82-2-792-5128    Fax: +82-2-792-4089    E-mail: journal@anesthesia.or.kr                

Copyright © 2022 by Korean Society of Anesthesiologists.

Developed in M2PI

Close layer
prev next