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Korean Journal of Anesthesiology 2001;40(3):389-396.
DOI: https://doi.org/10.4097/kjae.2001.40.3.389   
The Effect of Preemptive Local Infiltration of Lidocaine and Gabapentin on Postoperative Pain in Rats.
Hae Kyu Kim, Hyun Sub Lee, Inn Se Kim, Seong Wan Baik, Jae Young Kwon, Sang Uk Shin
Department of Anesthesiology, College of Medicine, Pusan National University, Busan, Korea.
Preemptive analgesia may improve postoperative antinociceptive treatment that prevents the development of central sensitization which contributes to post-injury pain hypersensitivity. However, beneficial effects of preemptive analgesia appear controversial. The purpose of this study was to examine the effect of pre- and post-incisional local infiltration of lidocaine and gabapentin on incisional pain in rats.
Thirty five male rats were divided into 7 groups; control group (n = 5), pre-lidocaine infiltration group (n = 5), post-lidocaine infiltration group (n = 5), pre-gabapentin 10 mg infiltration group (n = 5), post-gabapentin 10 mg infiltration group (n = 5), pre-gabapentin 30 mg infiltration group (n = 5), and post-gabapentin 30 mg infiltration group (n = 5). To evaluate postoperative mechanical hyperalgesia in injured feet, withdrawal thresholds were measured by calibrated von Frey filaments at 2 hrs, 1, 2, 3, 4, and 5 days after an incision.
The pre-lidocaine infiltration group shows better analgesic effects than post-lidocaine infiltration group until postoperative day 1 (P < 0.05). The gabapentin infiltration groups were effective in postoperative pain management but there were no significant differences between pre- and post- incisional treatment.
A preemptive lidocaine injection has a good analgesic effect on incisional pain. Gabapentin also has a good analgesic effect on incisional pain.
Key Words: Analgesia: preemptive; Anesthetics, local: lidocaine; Animals: rats; Anticonvulsants: gabapentin


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