| Protective Effect of Etomidate on Kainic Acid-induced Neurotoxicity in Rat Hippocampus. |
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Eun Ju Lee, Joung Uk Kim, Mi Jeung Gwak, Sung Min Han, Jong Whan Lee, Hee Nam Hong, Donghou Kim |
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Departments of Anesthesiology and *Anatomy, College of Medicine, University of Ulsan, Korea. |
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| Abstract |
BACKGROUND
The present investigation was undertaken to evaluate the neuroprotective effect of etomidate against kainic acid (KA) induced neurotoxicity in rats by using the immunoreactivity of heat shock protein-70 (HSP-70) and the acid-fuchsin stain.
METHODS
Administration of etomidate (20 mg/kg, I.P.) was performed in sequence; first being just one hour after a KA (10 mg/kg, I.P.) injection, then three more times at one hour intervals. Neuronal damages in the hippocampus were evaluated by using the acid-fuchsin stain to detect cell death and HSP-70 induction as an index of cell injury at 24 h after the administration of KA.
RESULTS
HSP-70 induction and acid fuchsin positive neurons were increased in the CA1 and CA3 regions of the hippocampus after a KA injection but significantly decreased by an injection of etomidate (P < 0.01).
CONCLUSIONS
These results suggest that the etomidate has a potential effect on the protection of neurons against KA-induced neurotoxicity. |
| Key Words:
Anesthetics, intravenous: etomidate; Animals: rats; Brain: hippocampus; Protein: heat shock protein-70; Toxicity: Kainic acid; neurotoxicity |
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