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Korean J Anesthesiol > Volume 40(6); 2001 > Article
Korean Journal of Anesthesiology 2001;40(6):794-801.
DOI: https://doi.org/10.4097/kjae.2001.40.6.794   
Protective Effect of Etomidate on Kainic Acid-induced Neurotoxicity in Rat Hippocampus.
Eun Ju Lee, Joung Uk Kim, Mi Jeung Gwak, Sung Min Han, Jong Whan Lee, Hee Nam Hong, Donghou Kim
Departments of Anesthesiology and *Anatomy, College of Medicine, University of Ulsan, Korea.
Abstract
BACKGROUND
The present investigation was undertaken to evaluate the neuroprotective effect of etomidate against kainic acid (KA) induced neurotoxicity in rats by using the immunoreactivity of heat shock protein-70 (HSP-70) and the acid-fuchsin stain.
METHODS
Administration of etomidate (20 mg/kg, I.P.) was performed in sequence; first being just one hour after a KA (10 mg/kg, I.P.) injection, then three more times at one hour intervals. Neuronal damages in the hippocampus were evaluated by using the acid-fuchsin stain to detect cell death and HSP-70 induction as an index of cell injury at 24 h after the administration of KA.
RESULTS
HSP-70 induction and acid fuchsin positive neurons were increased in the CA1 and CA3 regions of the hippocampus after a KA injection but significantly decreased by an injection of etomidate (P < 0.01).
CONCLUSIONS
These results suggest that the etomidate has a potential effect on the protection of neurons against KA-induced neurotoxicity.
Key Words: Anesthetics, intravenous: etomidate; Animals: rats; Brain: hippocampus; Protein: heat shock protein-70; Toxicity: Kainic acid; neurotoxicity
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